Maleimide-DOTA

Maleimide-DOTA is a bifunctional chelating agent that can be used for protein conjugation and labeling of radioactive metals ^[1]. The maleimide-DOTA molecule consists of a maleimide group that reacts specifically with sulfhydryl (-SH) groups on proteins, peptides, and other molecules to form a stable thioether bond ^[2]. DOTA (dodecanetetraacetic acid, also known as tetraoxycyclohexane) is a chelating agent that is particularly suitable for lanthanide ions and is also suitable for the chelation of radioactive metals such as ⁶⁸Ga, ¹¹¹In, and ¹⁷⁷Lu. DOTA forms a stable complex with radioactive gold and can be used in the development of radiopharmaceuticals ^{[3, 4]}. Maleimide-DOTA can be used to label radiotherapeutic agents or imaging probes and detect labeled tumors by PET, SPECT, and CT methods^[5]. The chemical formula of maleimide-DOTA is C₂₂H₃₄N₆O₉ and the molecular weight is 526.54. This product is for research use only and is not intended for use as food, drug, medical device, or cosmetic.

References:
[1] Nakashima K, Watanabe H, Ono M. Development of Novel Trifunctional Chelating Agents That Enhance Tumor Retention of Radioimmunoconjugates[J]. Journal of Medicinal Chemistry, 2023, 66(18): 12812-12827.
[2] Dijkgraaf I, Agten S M, Bauwens M, et al. Strategies for Site-Specific Radiolabeling of Peptides and Proteins[J]. Radiopharmaceuticals—Current Research for Better Diagnosis and Therapy, 2022.
[3] Wängler C, Schäfer M, Schirrmacher R, et al. DOTA derivatives for site-specific biomolecule-modification via click chemistry: synthesis and comparison of reaction characteristics[J]. Bioorganic & medicinal chemistry, 2011, 19(12): 3864-3874.
[4] Orlova A, Jonsson A, Rosik D, et al. Site-specific radiometal labeling and improved biodistribution using ABY-027, a novel HER2-targeting Affibody molecule–albumin-binding domain fusion protein[J]. Journal of Nuclear Medicine, 2013, 54(6): 961-968.
[5] Wållberg H, Ståhl S. Design and evaluation of radiolabeled tracers for tumor imaging[J]. Biotechnology and applied biochemistry, 2013, 60(4): 365-383.

马来酰亚胺-DOTA（Maleimide-DOTA）是一种双功能螯合剂，可用于蛋白质的缀合以及放射性金属的标记^[1]。Maleimide-DOTA分子由马来酰亚胺基团组成，其特异性地与蛋白质、肽和其他分子上的巯基（-SH）反应，形成稳定的硫醚键^[2]。DOTA（十二烷四乙酸，也称为四氧环己烷）是一种络合剂，特别适用于镧系离子，也适用于放射性金属如⁶⁸Ga、¹¹¹In和¹⁷⁷Lu的螯合，DOTA与放射性金形成稳定的复合物可用于放射性药物的开发^{[3, 4]}。Maleimide-DOTA可用于标记放射治疗剂或成像探针，并通过PET、SPECT和CT方法检测标记的肿瘤^[5]。Maleimide-DOTA的化学式为C₂₂H₃₄N₆O₉，分子量为526.54。本产品仅供研究用途，不适用于食品、药品、医疗器械或化妆品。