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Mapatumumab

(Synonyms: 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody) 目录号 : GC74475

Mapatumumab (HGS-ETR1)是一种完全人IgG1激动性单克隆抗体,靶向肿瘤坏死因子相关凋亡诱导配体受体1 (TRAIL-R1)。

Mapatumumab Chemical Structure

Cas No.:658052-09-6

规格 价格 库存 购买数量
1 mg
¥2,700.00
现货
5 mg
¥8,100.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer.

Mapatumumab (0.01-100 μg/mL; 4 h) shows no growth inhibition to Pediatric Preclinical Testing Program (PPTP) cell lines[1].Mapatumumab (1-100 ng/mL; 24 h) shows significant potentiation of cytotoxicity and synergy when combined with (epirubicin) EPI for bladder cancer cells[2].Mapatumumab (100 ng/mL; 12 h) induces significant cell apoptosis of T24, 253J and J82 cells with the combination of EPI (1 μg/mL)[2].Mapatumumab (100 ng/mL; 6-24 h) significantly activates caspase-8, -9 and -3 with the combination of EPI (1 μg/mL)[2].

Mapatumumab (10 mg/kg; i.p. for three times) controls tumor growth when combined with irradiation[3].

References:
[1]. Smith MA, et al. Initial testing (stage 1) of mapatumumab (HGS-ETR1) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2010 Feb;54(2):307-10. [2]. Ahmed SM, et al. Synergistic induction of apoptosis by mapatumumab and anthracyclines in human bladder cancer cells. Oncol Rep. 2015 Feb;33(2):566-72.
[3]. Marini P, et al. Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and poxic conditions. Int J Radiat Oncol Biol Ps. 2009 Sep 1;75(1):198-202.

化学性质

Cas No. 658052-09-6 SDF
别名 马帕木单抗; HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody
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