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MART-1 (26-35) human Sale

目录号 : GC31829

MART-1(26-35)是MART-1蛋白26至35氨基酸片段。

MART-1 (26-35) human Chemical Structure

Cas No.:156251-01-3

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1mg
¥803.00
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5mg
¥3,213.00
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Sample solution is provided at 25 µL, 10mM.

Description

MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 protein.

MART-1 (Melan-A) gene is 18 kb long and comprises five exons. It is expressed in most melanoma tumor samples, and among normal cells, only in melanocytes[1]. In cancer immunotherapy, epitopes and variants derived from the MART-1/Melan-A protein are widely used as clinical vaccines. The epitopes spanning amino acid residues 26-35 and 27-35 from the MART-1/Melan-A protein, highly expressed in melanoma cells, provide a prime example of T cell recognition of multiple peptides and the use of peptide variants designed to elicit altered immunological responses[2].

[1]. Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42. [2]. Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36.

化学性质

Cas No. 156251-01-3 SDF
Canonical SMILES Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val
分子式 C42H74N10O14 分子量 943.1
溶解度 Soluble in Water 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.0603 mL 5.3017 mL 10.6033 mL
5 mM 0.2121 mL 1.0603 mL 2.1207 mL
10 mM 0.106 mL 0.5302 mL 1.0603 mL
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