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Mastoparan 7 (trifluoroacetate salt)

(Synonyms: Mas7) 目录号 : GC91846

Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan.

Mastoparan 7 (trifluoroacetate salt) Chemical Structure

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500 µg
¥1,386.00
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1 mg
¥2,632.00
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5 mg
¥8,316.00
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10 mg
¥13,860.00
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Sample solution is provided at 25 µL, 10mM.

Description

Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan.[1] It decreases the affinity of acetylcholine (ACh) to porcine brain muscarinic ACh receptors (mAChRs) when used at a concentration of 30 µM and induces GDP/GTP exchange by Gi in a concentration-dependent manner. Mastoparan 7 (1 µM) also induces activation of Gαo in, and increases dendritic spine density of, primary rat hippocampal neurons.[2] It induces contractions in isolated perfused rat tail arteries (EC50 = 44.1 nM).[3] Immunization with a vaccine against cocaine in combination with mastoparan 7 as an adjuvant increases hapten-specific serum IgG levels and decreases cocaine-induced locomotion in mice.[4]

References:
[1].Higashijima, T., Burnier, J., and Ross, E.M.Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activityJ. Biol. Chem.265(24)14176-14186(1990).
[2].Ramírez, V.T., Ramos-Fernández, E., and Inestrosa, N.C.The Gαo activator mastoparan-7 promotes dendritic spine formation in hippocampal neuronsNeural Plast.4258171(2016).
[3].Grześk, G., Malinowski, B., Grześk, E., et al.Direct regulation of vascular smooth muscle contraction by mastoparan-7Biomed. Rep.2(1)34-38(2014).
[4].St. John, A.L., Choi, H.W., Walker, Q.D., et al.Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacyNPJ Vaccines5(1)12(2020).

化学性质

Cas No. N/A SDF Download SDF
别名 Mas7
分子式 C67H124N18O15•XCF3COOH 分子量 1421.8
溶解度 Water: Soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.7033 mL 3.5167 mL 7.0333 mL
5 mM 0.1407 mL 0.7033 mL 1.4067 mL
10 mM 0.0703 mL 0.3517 mL 0.7033 mL
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