MDMB-4en-PINACA-d4 (CRM)
(Synonyms: MDMB-PENINACA-d4,MDMB-PINACA N1-pentyl-4-en isomer-d4) 目录号 : GC91750MDMB-4en-PINACA-d4 (CRM) is intended for use as an internal standard for the quantification of MDMB-4en-PINACA in a drug discrimination test and induces hypothermia in mice.
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
MDMB-4en-PINACA-d4 (CRM) is intended for use as an internal standard for the quantification of MDMB-4en-PINACA in a drug discrimination test and induces hypothermia in mice.[2] MDMB-4en-PINACA has been associated with overdose and found in samples seized by law enforcement.3,4 MDMB-4en-PINACA-d4 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.
References:
[1].Cannaert, A., Sparkes, E., Pike, E., et al.Synthesis and in vitro cannabinoid receptor 1 activity of recently detected synthetic cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICAACS Chem. Neurosci.11(24)4434-4446(2020).
[2].Marusich, J.A., Gamage, T.F., Zhang, Y., et al.In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonistsPharmacol. Biochem. Behav.220173467(2022).
[3].Manini, A.F., Krotulski, A.J., Schimmel, J., et al.Respiratory failure in confirmed synthetic cannabinoid overdoseClin. Toxicol. (Phila)60(4)524-526(2022).
[4].Rodrigues, T.B., Souza, M.P., de Melo Barbosa, L., et al.Synthetic cannabinoid receptor agonists profile in infused papers seized in Brazilian prisonsForensic Toxicol.40(1)119-124(2022).
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7663 mL | 13.8313 mL | 27.6625 mL |
| 5 mM | 0.5533 mL | 2.7663 mL | 5.5325 mL |
| 10 mM | 0.2766 mL | 1.3831 mL | 2.7663 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。