Megestrol Acetate
(Synonyms: 醋酸甲地孕酮) 目录号 : GC11688
A synthetic progestogen
Cas No.:595-33-5
Sample solution is provided at 25 µL, 10mM.
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Megestrol Acetate is a synthetic progesteronal and potent anti-estrogen agent with multiple drug actions [1].
Megestrol Acetate has been reported to cause minor reduction of tumor size and prolonged survival time in Hepatocellular carcinoma (HCC). In addition, Megestrol Acetate has shown the dose-dependent inhibition on growth of the human liver tumor cells in the HepG2 cell lines with the IC50 value of 260μM in vitro. Furthermore, Megestrol Acetate has also shown a significant suppression of tumor growth. The tumor volumes of the addition of Megestrol Acetate group regressed to 59% of controls at 6th week. Apart from these, Megestrol Acetate has been revealed to increase the cell numbers of sub-G1 and inhibit the cell cycle progression in both dose- and time–dependent fashion. Besides, Megestrol Acetate has been demonstrated to induce apoptosis of HepG2 cells [1].
References:
[1] Zhang K1, Chow PK. The effect of megestrol acetate on growth of HepG2 cells in vitro and in vivo. Clin Cancer Res. 2004 Aug 1; 10(15):5226-32.
| Cas No. | 595-33-5 | SDF | |
| 别名 | 醋酸甲地孕酮 | ||
| 化学名 | [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate | ||
| Canonical SMILES | CC1=CC2C(CCC3(C2CCC3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C | ||
| 分子式 | C24H32O4 | 分子量 | 384.51 |
| 溶解度 | ≥ 3.84mg/mL in DMSO with gentle warming | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6007 mL | 13.0036 mL | 26.0071 mL |
| 5 mM | 0.5201 mL | 2.6007 mL | 5.2014 mL |
| 10 mM | 0.2601 mL | 1.3004 mL | 2.6007 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet