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Meglutol-d3 Sale

(Synonyms: 氘代3-羟基-3-甲基(D3)) 目录号 : GC49486

An internal standard for the quantification of meglutol

Meglutol-d3 Chemical Structure

Cas No.:59060-36-5

规格 价格 库存 购买数量
5 mg
¥952.00
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10 mg
¥1,443.00
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25 mg
¥3,078.00
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50 mg
¥5,663.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Meglutol-d3 is intended for use as an internal standard for the quantification of meglutol by GC- or LC-MS. Meglutol is an HMG-CoA reductase inhibitor (IC50 = 4 nM) and antimetabolite of mevalonic acid.1 Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day.2 It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day.3 Intracerebroventricular administration of meglutol (0.5 µmol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups.4 Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.4

1.Medina-Franco, J.L., LÓpez-Vallejo, F., RodrÍguez-Morales, S., et al.Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductaseBioorg. Med. Chem. Lett.15(4)989-994(2005) 2.Beg, Z.H., and Siddiqi, M.Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidExperientia23(5)380(1967) 3.Lupien, P.J., Tremblay, M., and Beg, Z.H.3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis18(3)407-416(1973) 4.da Rosa, M.S., da Rosa-Junior, N.T., Parmeggiani, B., et al.3-Hydroxy-3-methylglutaric acid impairs redox and energy homeostasis, mitochondrial dynamics, and endoplasmic reticulum-mitochondria crosstalk in rat brainNeurotox. Res.37(2)314-325(2020)

Chemical Properties

Cas No. 59060-36-5 SDF Download SDF
别名 氘代3-羟基-3-甲基(D3)
Canonical SMILES OC(CC(C([2H])([2H])[2H])(O)CC(O)=O)=O
分子式 C6H7D3O5 分子量 165.2
溶解度 DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 10mg/mL 储存条件 -20°C
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1 mM 6.0533 mL 30.2663 mL 60.5327 mL
5 mM 1.2107 mL 6.0533 mL 12.1065 mL
10 mM 0.6053 mL 3.0266 mL 6.0533 mL
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