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Meglutol (Dicrotalic acid) Sale

(Synonyms: 3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid) 目录号 : GC34035

An HMG-CoA reductase inhibitor

Meglutol (Dicrotalic acid) Chemical Structure

Cas No.:503-49-1

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100mg
¥446.00
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Sample solution is provided at 25 µL, 10mM.

Description

Meglutol is an HMG-CoA reductase inhibitor (IC50 = 4 nM) and antimetabolite of mevalonic acid.1 Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day.2 It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day.3 Intracerebroventricular administration of meglutol (0.5 ?mol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups.4 Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.4

1.Medina-Franco, J.L., López-Vallejo, F., Rodríguez-Morales, S., et al.Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductaseBioorg. Med. Chem. Lett.15(4)989-994(2005) 2.Beg, Z.H., and Siddiqi, M.Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidExperientia23(5)380(1967) 3.Lupien, P.J., Tremblay, M., and Beg, Z.H.3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis18(3)407-416(1973) 4.da Rosa, M.S., da Rosa-Junior, N.T., Parmeggiani, B., et al.3-Hydroxy-3-methylglutaric acid impairs redox and energy homeostasis, mitochondrial dynamics, and endoplasmic reticulum-mitochondria crosstalk in rat brainNeurotox. Res.37(2)314-325(2020)

化学性质

Cas No. 503-49-1 SDF
别名 3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid
Canonical SMILES O=C(O)CC(C)(O)CC(O)=O
分子式 C6H10O5 分子量 162.14
溶解度 DMSO: 250 mg/mL (1541.88 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 6.1675 mL 30.8375 mL 61.6751 mL
5 mM 1.2335 mL 6.1675 mL 12.335 mL
10 mM 0.6168 mL 3.0838 mL 6.1675 mL
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