Merbromin (Mercury dibromofluorescein disodium salt)
(Synonyms: 2,7-二溴-4-羟汞基荧光红双钠盐,Mercury dibromofluorescein disodium salt; ZP1) 目录号 : GC30170
Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro.
Cas No.:129-16-8
Sample solution is provided at 25 µL, 10mM.
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Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro.
Merbromin strongly inhibites the proteolytic activity of 3CLpro which is a promising target for developing anti-SARS-CoV-2 drugs. Michaelis-Menten kinetic analysis shows that Merbromin is a mixed-type inhibitor of 3CLpro, indicating by its ability of increasing the KM and decreasing the Kcat of 3CLpro. And 3CLpro possessed two binding sites for Merbromin.[2]
[1] Chen J, et al. Biochem Biophys Res Commun. 2022 Feb 5;591:118-123. [2] Chen J, et al. Biochem Biophys Res Commun. 2022 Feb 5;591:118-123.
| Cas No. | 129-16-8 | SDF | |
| 别名 | 2,7-二溴-4-羟汞基荧光红双钠盐,Mercury dibromofluorescein disodium salt; ZP1 | ||
| Canonical SMILES | O[Hg]C1=C([O-])C(Br)=CC(C2C3=C(C=CC=C3)C([O-])=O)=C1OC4=C2C=C(Br)C(O)=C4.[Na+].[Na+] | ||
| 分子式 | C20H10Br2HgNa2O6 | 分子量 | 752.67 |
| 溶解度 | Water : ≥ 50 mg/mL (66.43 mM);DMSO : 6.67 mg/mL (8.86 mM) | 储存条件 | Store at -20°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3286 mL | 6.643 mL | 13.286 mL |
| 5 mM | 0.2657 mL | 1.3286 mL | 2.6572 mL |
| 10 mM | 0.1329 mL | 0.6643 mL | 1.3286 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet