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Metaxalone-d6 Sale

(Synonyms: AHR438-d6; NSC170959-d6) 目录号 : GC48907

An internal standard for the quantification of metaxalone

Metaxalone-d6 Chemical Structure

Cas No.:1189944-95-3

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1mg
¥3,751.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.1,2 It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM.2 Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

1.Chou, R., Peterson, K., and Helfand, M.Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic reviewJ. Pain Symptom Manage.28(2)140-175(2004) 2.Yamaguchi, M., and Levy, R.M.Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophylleneCurr. Mol. Med.20(8)643-652(2020)

Chemical Properties

Cas No. 1189944-95-3 SDF
别名 AHR438-d6; NSC170959-d6
Canonical SMILES [2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC(O2)CNC2=O)=C1
分子式 C12H9D6NO3 分子量 227.3
溶解度 Acetonitrile: Soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.3995 mL 21.9974 mL 43.9947 mL
5 mM 0.8799 mL 4.3995 mL 8.7989 mL
10 mM 0.4399 mL 2.1997 mL 4.3995 mL
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