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Metformin D6 hydrochloride Sale

(Synonyms: 二甲双胍盐酸,1,1-Dimethylbiguanide-d6 hydrochloride) 目录号 : GC61045

An internal standard for the quantification of metformin

Metformin D6 hydrochloride Chemical Structure

Cas No.:1185166-01-1

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1mg
¥1,260.00
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5mg
¥3,600.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Metformin-d6 is intended for use as an internal standard for the quantification of metformin by GC- or LC-MS. Metformin is a biguanide with diverse biological activities.1,2,3,4 Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice.2 It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day.4 It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD).5 Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I.3 Formulations containing metformin have been used in the treatment of type 2 diabetes.

1.Viollet, B., Guigas, B., Garcia, N.S., et al.Cellular and molecular mechanisms of metformin: An overviewClin. Sci. (Lond.)122(6)253-270(2012) 2.Shaw, R.J., Lamia, K.A., Vasquez, D., et al.The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metforminScience3101642-1646(2005) 3.Wheaton, W.W., Weinberg, S.E., Hamanaka, R.B., et al.Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisElife3:e02242(2014) 4.Kim, E.K., Lee, S.H., Jhun, J.Y., et al.Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21.Mediators Inflamm.5813030(2016) 5.Lin, M.-J., Dai, W., Scott, M.J., et al.Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRα signaling pathwayOncotarget8\(65)108802-108809(2017)

Chemical Properties

Cas No. 1185166-01-1 SDF
别名 二甲双胍盐酸,1,1-Dimethylbiguanide-d6 hydrochloride
Canonical SMILES NC(NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)=N.[H]Cl
分子式 C4H6D6ClN5 分子量 171.66
溶解度 H2O : 50 mg/mL (291.27 mM; Need ultrasonic); DMSO : 50 mg/mL (291.27 mM; ultrasonic and warming and heat to 60°C) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.8255 mL 29.1273 mL 58.2547 mL
5 mM 1.1651 mL 5.8255 mL 11.6509 mL
10 mM 0.5825 mL 2.9127 mL 5.8255 mL
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