Methoxyflurane
(Synonyms: 甲氧氟烷) 目录号 : GC38814
Methoxyflurane 是一种卤化的挥发性麻醉剂，在亚麻醉剂量下具有有效的镇痛作用。Methoxyflurane 在小型实验动物中广泛用作麻醉剂，已有数十年历史。Methoxyflurane 具有肾毒性的风险。
Cas No.:76-38-0
Sample solution is provided at 25 µL, 10mM.
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Methoxyflurane is a halogenated volatile anaesthetic agent with potent analgesic effects at sub-anaesthetic doses. Methoxyflurane widely used as an open-circuit anaesthetic in small laboratory animals for several decades. Methoxyflurane has the risk of nephrotoxicity[1][2].
Methoxyflurane is delivered via a hand-held inhaler[3].
The developmental toxicity of trace, subanesthetic, and anesthetic exposure to Methoxyflurane is examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of Methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of Methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring[4].
[1]. Occupational exposure to methoxyflurane administered for procedural sedation: an observational study of 40 exposures. Br J Anaesth. 2018 Jun;120(6):1435-1437. [2]. Porter KM, et al. The role of inhaled methoxyflurane in acute pain management. Open Access Emerg Med. 2018 Oct 18;10:149-164. [3]. Methoxyflurane nephrotoxicity. JAMA. 1971 Aug 16;217(7):958-9. [4]. Wharton RS, et al., Developmental toxicity of methoxyflurane in mice. Anesth Analg. 1980 Jun;59(6):421-5.
| Cas No. | 76-38-0 | SDF | |
| 别名 | 甲氧氟烷 | ||
| Canonical SMILES | COC(F)(F)C(Cl)Cl | ||
| 分子式 | C3H4Cl2F2O | 分子量 | 164.97 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.0617 mL | 30.3085 mL | 60.6171 mL |
| 5 mM | 1.2123 mL | 6.0617 mL | 12.1234 mL |
| 10 mM | 0.6062 mL | 3.0309 mL | 6.0617 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet