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Methyldopate Sale

(Synonyms: αMethyldopa ethyl ester) 目录号 : GC41639

A prodrug form of methyldopa

Methyldopate Chemical Structure

Cas No.:6014-30-8

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1mg
¥246.00
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5mg
¥1,112.00
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10mg
¥1,854.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Methyldopate is an ethyl ester prodrug form of methyldopa , a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo., Formulations containing methyldopate have been used in the treatment of hypertension.

Chemical Properties

Cas No. 6014-30-8 SDF
别名 αMethyldopa ethyl ester
Canonical SMILES OC1=C(O)C=CC(C[C@](C)(N)C(OCC)=O)=C1
分子式 C12H17NO4 分子量 239.3
溶解度 DMSO: Slightly Soluble,Methanol: Slightly Soluble 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 4.1789 mL 20.8943 mL 41.7885 mL
5 mM 0.8358 mL 4.1789 mL 8.3577 mL
10 mM 0.4179 mL 2.0894 mL 4.1789 mL
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Research Update

Metabolic disposition and cardiovascular effects of Methyldopate in unanesthetized rhesus monkeys

J Pharmacol Exp Ther 1975 Oct;195(1):151-8.PMID:810574doi

Methyldopate, the ethyl ester hydrochloride salt of alpha-methyldopa (alpha-MD), is used extensively in the treatment of severe hypertension. We have developed a high-pressure liquid chromatographic assay to determine the plasma-time concentrations of alpha-MD after intravenous administration of Methyldopate and alpha-MD in the monkey in an effort to evaluate the bioavailability of alpha-MD and the extent of in vivo hydrolysis of the amino ester to the amino acid. The results establish that in this experimental situation Methyldopate is not metabolically equivalent to alpha-MD.

Stability of pediatric liquid dosage forms of ethacrynic acid, indomethacin, Methyldopate hydrochloride, prednisone and spironolactone

Am J Hosp Pharm 1978 Nov;35(11):1382-5.PMID:568384doi

The stability of liquid dosage forms of ethacrynic acid (1 mg/ml), indomethacin (2 mg/ml), Methyldopate hydrochloride (25 mg/ml), prednisone (0.5 mg/ml) and spironolactone (2 mg/ml), which often are compounded extemporaneously, was studied. One or two liquid dosage forms of each of the five drugs was prepared with the pure drug or the powder from a commercial dosage form using aqueous sorbitol or simple syrup alone or with a 10% (v/v) solution of alcohol in water. The dosage forms were stored at 24 C in amber-colored bottles for 21-224 days and assayed by various methods. All solutions studied were stable for at least 84 days. A solution was considered stable if it retained 90% of its drug concentration. Except for the prednisone solution, all solutions were stable for at least 164 days; however, the solution of Methyldopate hydrochloride prepared from the pure drug became discolored after 98 days. The liquid dosage forms studied have limited stability but can be used by the pharmacist when extemporaneous oral solutions of these drugs are needed.

Spurious increase in serum creatinine associated with intravenous Methyldopate therapy

Drug Intell Clin Pharm 1984 Nov;18(11):896-7.PMID:6499654DOI:10.1177/106002808401801109.

A patient with subarachnoid hemorrhage treated with intravenous Methyldopate experienced a sudden marked increase in serum creatinine. This increase was due to interference by Methyldopate in the assay for serum creatinine. By performing in vitro interference studies, we confirmed that Methyldopate interferes with the creatinine assay.

Plasma concentration of alpha-methyldopa and sulphate conjugate after oral administration of methyldopa and intravenous administration of methyldopa and methyldopa hydrochloride ethyl ester

Eur J Clin Pharmacol 1975 Aug 14;8(6):381-6.PMID:1233238DOI:10.1007/BF00562310.

The plasma concentrations of free alpha-methyldopa and methyldopa sulphate conjugate were measured in 7 hypertensive patients with normal renal function following alpha-methyldopa (1 g) orally. Five of these patients subsequently received alpha-methyldopa ethyl ester (250 mg) (Methyldopate) intravenously and two further patients received 250 mg of alpha-methyldopa intravenously. After oral administration a large amount of total plasma alpha-methyldopa was present as sulphate conjugate. There were wide interindividual differences in the ratio of free: conjugated alpha-methyldopa in plasma (ratio at 4 hours ranged from 3.73-0.83) suggesting that individual differences in the extent of sulphate conjugation may occur. There was no close correlation between the degree of conjugation and the fall in arterial pressure. At all time intervals examined, plasma concentrations were higher following intravenous alpha-methyldopa than alpha-methyldopate. The plasma concentration of alpha-methyldopa (free and esterified) 60 minutes after i.v. alpha-methyldopate was 1.7+/-0.3 mug/ml while at the same time after the same dose of methyldopa by the same route the mean concentration was 5.9 mug/ml. Although small amounts of sulphate conjugate were detected after i.v. alpha-methyldopate, insignificant quantities of conjugate were found after i.v. alpha-methyldopa. The average fall in mean arterial pressure was 27 mm/Hg following i.v. alpha-methyldopa but only 2.7 mm Hg following alpha-methyldopate. These results suggest that sulphate conjugation of alpha-methyldopa occurs in the gastrointestinal tract during absorption. Hydrolysis of alpha-methyldopa ethyl ester does not appear to be instantaneous and pharmacokinetic differences between the ester and free alpha-methyldopa have been demonstrated.

Antagonism of conditioned salivation in conscious dogs by antihypertensive drugs

Can J Physiol Pharmacol 1977 Aug;55(4):968-71.PMID:902171DOI:10.1139/y77-132.

Methyldopate (methyldopa (ethyl ester)), carbidopa, clonidine, and ST-91 were evaluated for their effects on conditioned salivation in unanesthetized dogs. Clonidine produced dose-dependent inhibition of salivation 20 min after an intravenous injection. At equivalent and larger doses, ST-91, a clonidine analog which does not penetrate the blood-brain barrier, was ineffective in inhibiting conditioned salivation, suggesting that central rather than peripheral mechanisms are involved in clonidine-induced inhibition of salivation. Methyldopate also produced a dose-dependent inhibition of salivation in dogs. The mechanism involved in methyldopa-induced inhibition of salivation may involve both central and peripheral mechanisms because carbidopa, an inhibitor (like methyldopa) of peripheral aromatic decarboxylase (EC 4.1.1.28), significantly inhibited salivation.