Metrizoic acid
(Synonyms: 甲泛影酸; Metrizoate) 目录号 : GC38816
Metrizoic acid(Metrizoate) is a diagnostic radiopaque. The mechanism of action of metrizoic acid is as a X-Ray contrast activity.
Cas No.:1949-45-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Metrizoic acid(Metrizoate) is a diagnostic radiopaque. The mechanism of action of metrizoic acid is as a X-Ray contrast activity.
[1] Nitter-Hauge S, et al. Radiology. 1976 Dec;121(3 Pt. 1):537-40.
| Cas No. | 1949-45-7 | SDF | |
| 别名 | 甲泛影酸; Metrizoate | ||
| Canonical SMILES | O=C(O)C1=C(I)C(N(C(C)=O)C)=C(I)C(NC(C)=O)=C1I | ||
| 分子式 | C12H11I3N2O4 | 分子量 | 627.94 |
| 溶解度 | DMSO: 31.25 mg/mL (49.77 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5925 mL | 7.9625 mL | 15.9251 mL |
| 5 mM | 0.3185 mL | 1.5925 mL | 3.185 mL |
| 10 mM | 0.1593 mL | 0.7963 mL | 1.5925 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Metrizoic acid (Isopaque coronar) used in man for cardiac angiography
Radiology 1976 Dec;121(3 Pt. 1):537-40.PMID:790454DOI:10.1148/121.3.537.
Isopaque Coronar, a radiopaque agent, was given (10,000 injections) to 2,028 patients during angiocardiographic studies done over a three-year period. With two exceptions, all complications occurred during right coronary artery injection. Seven cases of ventricular fibrilation, and 5 of marked bradycardia/asystole, were associated with injection of the medium. Isopaque Coronar is well tolerated by patients during cardiac examinations. Factors which may help to explain the low complication rate are discussed.
Jodamid and Metrizoic acid in carotid angiography. Comparative study of side-effects and film contrast
Ann Clin Res 1977 Aug;9(4):246-51.PMID:616209doi
To compare the side-effects and film contrast of jodamid and Metrizoic acid 215 carotid angiography examinations were analyzed. To study the side-effects the pulse and blood pressure were recorded and the clinical condition of the patient was observed during the examination as well as on the subsequent day. Three neuroradiologists graded the film contrast without knowing the opinions of the others or which contrast medium had been used. No significant changes in pulse rate were recorded. A slight increase in blood pressure generally occurred immediately after the injection and a statistically significant but slight fall of blood pressure five to seven seconds after the injection. No differences were observed between the two contrast media. Injection into the common carotid artery lowered the blood pressure slightly more than injection into the internal carotid artery. No differences in clinical side-effects were noticed between the two contrast media. No irreversible side-effects were recorded. The film contrast of jodamid was significantly better than that of Metrizoic acid.
Development of Plasmodium berghei ookinetes to young oocysts in vitro
J Protozool 1992 Mar-Apr;39(2):333-8.PMID:1578408DOI:10.1111/j.1550-7408.1992.tb01325.x.
The mosquito stage of Plasmodium berghei was cultivated in vitro, with special attention to ookinete transformation into early oocyst. The ookinetes were obtained by in vitro culture of gametocytes taken from infected mice, purified by density gradient of Metrizoic acid or a lymphocyte separation medium, and incubated either in acellular culture or in co-cultivations with mosquito cells. In acellular culture, the ookinetes were found to aggregate with each other and transformed from banana to round shapes. Their inner pellicular membranes and subpellicular microtubules partially disappeared, indicating that development to early oocyst had occurred. Co-cultivation wtih Aedes albopictus cells (C6/36 clone) revealed that ookinetes transformed into early oocyst in the medium, or invaded the cells and then transformed to early oocysts within the cell cytoplasm as well. However all of these transformed cells failed to develop further, i.e., neither deposition of the oocyst capsule nor nuclear division was observed. Many ookinetes which failed to penetrate the Aedes cells were phagocytized within three days of culture. A significant difference between invaded and transformed oocysts and phagocytized ookinetes was seen in that the former lacked vacuole membrane. Co-cultivation with Toxorhynchites amboinensis cells (TRA-284-SFG clone) permitted transformation of ookinetes into early oocysts in the medium as in the acellular culture, but no ookinete invasion nor phagocytosis by the cell was observed.
The migration test on circulating bovine leukocytes and its possible application in the diagnosis of Johne's disease
Acta Vet Scand 1970;11(2):331-4.PMID:5449108DOI:10.1186/BF03547996.
The leukocyte migration test for in vitro studies of delayed type hypersensitivity has recently been reviewed (Søborg & Ben-dixen 1967; Bendixen & Søborg 1969). Søborg & Bendixen applied the test to circulating leukocytes in man and thereby widely increased the potentialities of this test. They obtained high leukocyte yields with only moderate erythrocyte admixture by harvesting the supernatant plasma after sedimentation of the erythrocytes for 60 min. at 37°C in the normal gravitational field (1 × g)- Their procedure was unsuitable for the present investigation because bovine erythrocytes sediment so slowly. Sedimentation after clumping at the interphase of aqueous solutions of polymers, dextran and methylcellulose, in combination with Metrizoic acid (Böyum 1968) was tried without success because the vast majority of the leukocytes sedimented together with the erythrocytes. Separation of leukocytes from erythrocytes could not be achieved by differential centrifugation.
Studies with an improved white cell isolation method to assess the vitamin C status in surveys
Int J Vitam Nutr Res 1977;47(3):236-47.PMID:410748doi
A method for isolating white cell which employs a disposable syringe has been modified and adapted to nutrition survey work. Methylcellulose was used as a clumping agent for erythrocytes. This method was more rapid and was easier to perform than a previously recommended Metrizoic acid technique which gave similar results. Average leucocyte recovery was 62% and erythrocyte contamination was 0.75 erythrocyte per leucocyte. Recovery of added ascorbic acid to white cell pellets was better than 95% and tests of the reproducibility of the assay gave a coefficient of variation of 6% for samples in the deficient range. Extraction of vitamin C from white cells was carried out in a centrifuge tube and took only 30 sec. Vitamin C was found to be stable for several weeks after freezing either the white cell extracts in dilute metaphosphoric acid or simply the white cell pellets. The method was utilized under field conditions during a small survey of Eskimos from Arctic Bay. The significance of the white cell vitamin C content as an index of nutritional status is discussed.