Mexoticin
(Synonyms: 近月橘素) 目录号 : GC61059
Mexoticin是一种天然的香豆素，可以从Murrayaomphalocarpa叶中分离得到。
Cas No.:18196-00-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Mexoticin, a naturally occurring coumarin, can be isolated from the leaves of Murraya omphalocarpa[1].
[1]. Keh-Shaw Chen, et al. Bioactive coumarins from the leaves of Murraya omphalocarpa. Planta Med. 2003 Jul;69(7):654-7.
| Cas No. | 18196-00-4 | SDF | |
| 别名 | 近月橘素 | ||
| Canonical SMILES | O=C1C=CC2=C(OC)C=C(OC)C(C[C@@H](O)C(C)(O)C)=C2O1 | ||
| 分子式 | C16H20O6 | 分子量 | 308.33 |
| 溶解度 | DMSO : 100 mg/mL (324.33 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2433 mL | 16.2164 mL | 32.4328 mL |
| 5 mM | 0.6487 mL | 3.2433 mL | 6.4866 mL |
| 10 mM | 0.3243 mL | 1.6216 mL | 3.2433 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
A Simple and Efficient Two-Dimensional High-Speed Counter-Current Chromatography Linear Gradient and Isocratic Elution Modes for the Preparative Separation of Coumarins from Roots of Toddalia asiatica (Linn.) Lam
Molecules 2021 Oct 2;26(19):5986.PMID:34641527DOI:10.3390/molecules26195986.
Toddalia asiatica (L.) Lam. (Rutaceae) has shown a broad spectrum of biological properties, such as anti-inflammatory, antioxidant, antimicrobial, anti-HIV, and anticancer properties. The present study is concerned with the separation of the main components with broad partition coefficients (KD values) from T. asiatica, using linear gradient high-speed counter-current chromatography (LGCCC) combined with an off-line two-dimensional (2D) mode. Similar to the binary gradient HPLC, the LGCCC mode is operated by the adjustment of the proportion between the mobile phase of 5:5:1:9 (v/v) (pump A) and 5:5:4.5:5.5 (v/v) (pump B) in an n-hexane/ethyl acetate/methanol/water solvent system. The off-line 2D-CCC mode was used in this study for the secondary separation of two similar KD value compounds with n-hexane/ethyl acetate/methanol/water (5:5:4:6, v/v). Notably, six coumarins, namely, tomentin (1), toddalolactone (2), 5,7,8-trimethoxycoumarin (3), Mexoticin (4), isopimpinellin (5), and toddanone (6), were efficiently separated. The structures of the pure compounds were elucidated by spectral techniques and compared with the literature.
A new bicoumarin from the leaves and stems of Triphasia trifolia
Fitoterapia 2006 Feb;77(2):129-33.PMID:16431036DOI:10.1016/j.fitote.2005.11.006.
A new bicoumarin (3) was isolated from the leaves and stems of Triphasia trifolia. Its structure was determined by spectral data, in particular two-dimensional NMR experiments. It appeared that the two coumarinic moieties of 3 are derivatives of Mexoticin (1) and meranzin hydrate (2), which are known constituents of the plant.
Bioactive coumarins from the leaves of Murraya omphalocarpa
Planta Med 2003 Jul;69(7):654-7.PMID:12898423DOI:10.1055/s-2003-41112.
Using antiplatelet aggregation as a guide to fractionation, eight coumarins, omphalocarpinol (1), 5,7-dimethoxy-8-(3'-methyl-2'-oxobutyl)coumarin (2), murralongin, murrayanone, omphamurin (5), murragleinin, Mexoticin, and murrangatin, were isolated from the leaves of Murraya omphalocarpa. Compound 1 is new, and 5 is a new enantiomer of omphamurin. The structures of these compounds were elucidated on the basis of spectroscopic techniques, and the structure of compound 1 was confirmed by X-ray crystallographic analysis. Among them, compounds 1, 2 and 5 exhibited significant antiplatelet aggregation activity.
[Studies on chemical constituents of Peucedanum delavayi]
Zhong Yao Cai 2008 Aug;31(8):1157-9.PMID:19112893doi
Objective: To study the chemical constituents of the radix and rhizome of Peucedanum delavayi. Methods: The chemical constituents had been separated by manifold chromato-graphy methods, and their structures were determined by spectral analysis. Results: Fifteen compounds were isolated and identified as Umbelliferone(I), Coumurayin(II), Mexoticin(III), Marmesin (IV), Ammijin(V), Delton (VI), Selinidin(VII), Anomalin(VII), Isopteryxin(IX), Ferulic acid(X), Falcarindiol(XI), Stearic acid(XII), beta-sitosterol(X III), Daucosterol(XIV) and d-Mannitol(XV). Conclusion: All these compounds are isolated from Peucedanum delavayi for the first time.