MGK-264
(Synonyms: 增效胺) 目录号 : GC47672
A dicarboxamide synergist
Cas No.:113-48-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
MGK-264 is a dicarboxamide synergist used to enhance the effects of pesticides.1 It is not lethal to house flies when used at a concentration of 5,000 ppm and induces only 26.4% mortality of two-spotted spider mites when used at a concentration of 1,000 ppm. MGK-264 has synergistic effects on toxicity when used in combination with the insecticide Plictran in susceptible strains of S. littoralis (LD50s = 0.98 and 40 µg/larva with or without MGK-264) and in field strains (LD50s = 0.15 and 1.1 µg/larva with or without MGK-264).2 It also decreases the fecundity of adult L. acuminata and reduces survival of the offspring after hatching when used in combination with sublethal doses of a variety of plant-derived molluscicides.3
1.Kilsheimer, J.A., and Kaufman, H.A.Pesticidal composition comprising a benzothienyl carbamate and synergist(1972) 2.Radwan, H.S.A., Riskallah, M.R., and El-Keie, I.A.Synergistic effects on the toxicity of organotins on cotton leafwormsToxicology14(3)193-198(1979) 3.Singh, K., and Singh, D.K.Effect of different combinations of MGK-264 or piperonyl butoxide with plant-derived molluscicides on snail reproductionArch. Environ. Contam. Toxicol.38(2)182-190(2000)
| Cas No. | 113-48-4 | SDF | |
| 别名 | 增效胺 | ||
| Canonical SMILES | O=C1N(CC(CCCC)CC)C(C2C3C=CC(C3)C21)=O | ||
| 分子式 | C17H25NO2 | 分子量 | 275.4 |
| 溶解度 | Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6311 mL | 18.1554 mL | 36.3108 mL |
| 5 mM | 0.7262 mL | 3.6311 mL | 7.2622 mL |
| 10 mM | 0.3631 mL | 1.8155 mL | 3.6311 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Effect of binary combination of deltamethrin+MGK-264 on the levels of phospholipid and lipid peroxidation in the snail Lymnaea acuminata
Chemosphere 2008 Oct;73(7):1032-5.PMID:18801555DOI:10.1016/j.chemosphere.2008.08.010.
Effect of sublethal treatment of (40% and 60% of 48 h LC50) of deltamethrin+MGK on phospholipid level and rate of lipid peroxidation in nervous and foot tissue of Lymnaea acuminata were studied. Maximum reduction in phospholipid (24.10%) level and increase in rate of lipid peroxidation (586.8%) were observed in foot tissue of snail exposed to 60% of 48 h LC50 of deltamethrin+MGK 264 for 96 h. Alterations in the levels of phospholipids and rate of lipid peroxidation were time and concentration dependent. Use of MGK-264 with deltamethrin increases the toxicity of deltamethrin and their action on membrane phospholipids and rate of lipid peroxidation.
Effect of different combinations of MGK-264 or piperonyl butoxide with plant-derived molluscicides on snail reproduction
Arch Environ Contam Toxicol 2000 Feb;38(2):182-90.PMID:10629280DOI:10.1007/s002449910024.
Effect of sublethal treatment (20% and 60% of LC(50)/24 h) of plant-derived molluscicides, viz. Polianthes tuberosa, Trachyspermum ammi, Allium sativum powder; Azadirachta indica oil; oleoresin of Zingiber officinale; and their active molluscicidal component in combination (1:5) with MGK-264 or piperonyl butoxide on the reproduction of snail Lymnaea acuminata have been studied. It was observed that the combination of plant derived molluscicide and their active molluscicidal components, viz. tigogenin, hecogenin, azadirachtin, allicin, thymol, and [6]-gingerol combination with MGK-264 or piperonyl butoxide caused a significant reduction in fecundity, hatchability, and survival of young snails. Withdrawal of snails to fresh water after the above treatment caused a significant recovery in the fecundity of L. acuminata.
Binary Combination of Carica papaya, Areca catechu and Myristica fragrans with Piperonyl Butoxide / MGK-264 against Freshwater Snail Lymnaea acuminata
Trop Life Sci Res 2013 Dec;24(2):1-11.PMID:24575245doi
Piperonyl butoxide (PB) and MGK-264 were used to enhance the toxicity of the active components papain, arecoline and myristicin from the plants Carica papaya, Areca catechu and Myristica fragrans, respectively, against the vector snail Lymnaea acuminata. A time- and dose-dependent relationship was observed for the toxicity of these combinations. The toxic effects of these plant-derived molluscicides in combination with the synergists PB and MGK-264 were several times higher than the effect of the individual treatments. The highest degree of synergism was observed when MGK-264 was used in combination with C. papaya latex (10.47-fold increase) and PB was used with papain (8.35-fold increase).
Effect of binary combination of some plant-derived molluscicides with MGK-264 or piperonyl butoxide on the reproduction of the snail Lymnaea acuminata
Pest Manag Sci 2005 Feb;61(2):204-8.PMID:15619718DOI:10.1002/ps.936.
The effects of sub-lethal treatments (20 and 60% of 24-h LC(50)) with plant-derived molluscicides Annona squamosa, acetogenins, Argemone mexicana seed and protopine, in combination (1 + 5) with MGK-264 (ENT 8184) or piperonyl butoxide on the reproduction of Lymnaea acuminata has been studied. The plant-derived molluscicides and their active molluscicidal components, protopine and acetogenins, in combination with ENT 8184 or piperonyl butoxide caused a significant reduction in the fecundity, hatchability and survival of young snails. Combination of A squamosa seed powder with piperonyl butoxide was very effective as it caused a complete arrest of snail fecundity within 24 h of treatment. Removal of the snails to fresh water after the 96-h treatments caused a significant recovery in the fecundity of L acuminata.
Combinations of Azadirachta indica and Cedrus deodara oil with piperonyl butoxide, MGK-264 and Embelia ribes against Lymnaea acuminata
Chemosphere 2001 Sep;44(8):1691-5.PMID:11534900DOI:10.1016/s0045-6535(00)00563-4.
The binary and tertiary combinations of plant-derived molluscicides Azadirachta indica and Cedrus deodara oil with synergists MGK-264, piperonyl butoxide (PB) and fruit powder of Embelia ribes were used against the Lymnaea acuminata. It was observed that the toxic effects of these mixtures were time- and dose-dependent. The binary and tertiary mixtures of plant-derived molluscicides with synergists were more toxic with respect to the single treatment of the plant-derived molluscicides. Maximum synergistic action in binary and tertiary combinations was found in A. indica + C. deodara oil and A. indica+ PB + C. deodara in 1:7 and 1:5:7 ratio, respectively.