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MI-192

目录号 : GC11949

A selective HDAC2/3 Inhibitor

MI-192 Chemical Structure

Cas No.:1415340-63-4

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1mg
¥619.00
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5mg
¥2,712.00
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10mg
¥4,806.00
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产品描述

MI-192 is a histone deacetylases (HDACs) inhibitor that preferentially inhibits HDAC2 and HDAC3 with IC50 values of 30 nM and 16 nM, respectively [1].

Histone acetylation is the most commonly employed mechanism utilized by transcription factors to activate gene expression. Conversely, histone deacetylation is the most common mechanism used to inactivate genes. Histone deacetylase inhibitors (HDACIs) are in advanced clinical development as cancer therapeutic agents [1].

MI-192 is a novel benzamide-based compound that had marked selectivity for the class I enzymes, HDAC2 and HDAC3. In HeLa cell extracts, MI-192 inhibited HDAC activity with IC50 value of 1.5 μM. MI-192 selectively inhibited recombinant HDAC2 and HDAC3 with IC50 values of 30 nM and 16 nM, respectively over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 μM, respectively). MI-192 showed the greatest growth inhibitory effect against the leukemic cell lines with an effective dose of 0.1-0.4 μM. MI-192 was cytotoxic and promoted apoptosis and differentiation in leukaemic cell lines [1]. In the human prostate cancer cell line PC3, MI-192 significantly increased tubulin acetylation and ablated the dynamic behaviour of microtubules in live cells [2].

References:
[1].  Boissinot, M.,Inman, M.,Hempshall, A., et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leukemia Research 36, 1304-1310 (2012).
[2].  Bacon T, Seiler C, Wolny M, et al. Histone deacetylase 3 indirectly modulates tubulin acetylation. Biochem J. 2015 Dec 15;472(3):367-77.

Chemical Properties

Cas No. 1415340-63-4 SDF
化学名 N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide
Canonical SMILES O=C1N(CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)CC(C4=CC=CC=C41)=C
分子式 C24H21N3O2 分子量 383.4
溶解度 ≤5mg/ml in DMSO;1mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mM 2.6082 mL 13.0412 mL 26.0824 mL
5 mM 0.5216 mL 2.6082 mL 5.2165 mL
10 mM 0.2608 mL 1.3041 mL 2.6082 mL
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