Midodrine (hydrochloride)
(Synonyms: 盐酸米多君; (±)-Midodrine hydrochloride) 目录号 : GC11239
A prodrug form of desglymidodrine
Cas No.:43218-56-0
Sample solution is provided at 25 µL, 10mM.
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Ki: 2, 6.9, and 1.7 μM for α1A, α1B, α1D, respectively
Midodrine is the prodrug of the α1-adrenergic receptor agonist, 1-(2’,5’-dimethoxyphenyl)-2-aminoethanol.
The α1-adrenergic receptor has some general functions similar with the α2-adrenergic receptor, but also has its own specific effects. α1-receptors primarily can mediate smooth muscle contraction and have other important functions as well.
In vitro: Midodrine was identified as a prodrug forming an active metabolite, desglymidodrine, which is an α1-receptor agonist exerting its actions through activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, leading to an increased vascular tone and elevation of blood pressure [1].
In vivo: A previous study was conducted to investigate the effect of intracerebroventricular injections of midodrine on the central nervous system of the rat. It was found that midodrine could decrease body temperature and increase locomotor activity, sedation in reserpinized rats as well as the cataleptic effect of haloperidol. Midodrine could also enhance amphetamine-stimulated locomotor activity and reduce the amphetamine and apomorphine sterotypy [1].
Clinical trial: The results of a previous pilot study indicated that midodrine combination with tolvaptan could better control ascites without any hepatic or renal dysfunction. Such combination therapy controled ascites rapidly as compared to midodrine or tolvaptan alone [2].
References:
[1] Kleinrok Z, Jagieo-Wójtowicz E, Oktaba-Polkowska A. Central action of intraventricularly-injected midodrine in rats. Arch Int Pharmacodyn Ther. 1980 Oct;247(2):217-33.
[2] Rai N, Singh B, Singh A, Vijayvergiya R, Sharma N, Bhalla A, Singh V. Midodrine and tolvaptan in patients with cirrhosis and refractory or recurrent ascites: a randomised pilot study. Liver Int. 2017 Mar;37(3):406-414.
| Cas No. | 43218-56-0 | SDF | |
| 别名 | 盐酸米多君; (±)-Midodrine hydrochloride | ||
| 化学名 | 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-acetamide, monohydrochloride | ||
| Canonical SMILES | OC(CNC(CN)=O)C1=C(OC)C=CC(OC)=C1.Cl | ||
| 分子式 | C12H18N2O4 • HCl | 分子量 | 290.7 |
| 溶解度 | ≥ 14.55mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.44 mL | 17.1999 mL | 34.3997 mL |
| 5 mM | 0.688 mL | 3.44 mL | 6.8799 mL |
| 10 mM | 0.344 mL | 1.72 mL | 3.44 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet