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Miglitol Sale

(Synonyms: 米格列醇,BAY1099; BAY-m1099) 目录号 : GC16373

An inhibitor of α-glucosidases

Miglitol Chemical Structure

Cas No.:72432-03-2

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥357.00
现货
10mg
¥546.00
现货
25mg
¥1,134.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose.Target: OthersMiglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect. Its effect will depend on the amount of non-monosaccharide carbohydrates in a person's diet. Dietary supplementation with miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets [1]. Miglitol was orally administered at 40 mg/100 g of high-fat diet containing 45% kcal as fat to 12-week-old rats for 29 days, and age-matched rats without the agent were used as the respective controls [2].

References:
[1]. Fukaya, N., et al., The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol, 2009. 624(1-3): p. 51-7.
[2]. Hirata, A., et al., Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res, 2009. 41(3): p. 213-20.

Chemical Properties

Cas No. 72432-03-2 SDF
别名 米格列醇,BAY1099; BAY-m1099
化学名 (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Canonical SMILES C1C(C(C(C(N1CCO)CO)O)O)O
分子式 C8H17NO5 分子量 207.22
溶解度 DMSO: 3 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 4.8258 mL 24.1289 mL 48.2579 mL
5 mM 0.9652 mL 4.8258 mL 9.6516 mL
10 mM 0.4826 mL 2.4129 mL 4.8258 mL
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