MMP 8 Human
目录号 : GP21939Matrix Metalloproteinase-8 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL-CL; HNC; CLG1. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. | ||
| Biological Activity | 100 units/ml after activation with APMA by solution assay method.One unit of collagenolytic activity is defined as the cleavage of 1?g of collagen per minute by the solution method. | ||
| Formulation | The MMP-8 protein solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, 0.2M NaCl, 5mM CaCl2, 0.0025% NaN3 and 0.1% BSA. | ||
Full-length recombinant human neutrophil MMP-8, latent form.Matrix metalloproteinase 8 (MMP-8), degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8.MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes.
100 units/ml after activation with APMA by solution assay method.One unit of collagenolytic activity is defined as the cleavage of 1?g of collagen per minute by the solution method.
Used as a standard for analyzing mammalian colagenase activity.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.