MMP14 Human
目录号 : GP21950Matrix Metalloproteinase-14 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Sf9,Baculovirus cells. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | MatrixMetallopeptidase 14; Matrix Metallopeptidase 14 (Membrane-Inserted); Membrane-Type-1Matrix Metalloproteinase; Membrane Type 1 Metalloprotease; EC 3.4.24.80; MT-MMP1; MT1-MMP; MMP-14; MMP-X1; MT1MMP; MTMMP1; Matrix Metalloproteinase 14(Membrane-Inserted); Membrane-Type Matrix Metalloproteinase 1; MatrixMetalloproteinase-14; EC 3.4.24; MT-MMP; WNCHRS; Matrix metalloproteinase-14; Membrane-typematrix metalloproteinase 1. | ||
| Amino Acid Sequence | ADLALASLGSAQSSSFSPEA WLQQYGYLPP GDLRTHTQRS PQSLSAAIAA MQKFYGLQVT GKADADTMKA MRRPRCGVPDKFGAEIKANV RRKRYAIQGL KWQHNEITFC IQNYTPKVGE YATYEAIRKA FRVWESATPL RFREVPYAYIREGHEKQADI MIFFAEGFHG DSTPFDGEGGFLAHAYFPGP NIGGDTHFDS AEPWTVRNED LNGNDIFLVA VHELGHALGLEHSSDPSAIM APFYQWMDTE NFVLPDDDRR GIQQLYGGES GFPTKMPPQP RTTSRPSVPD KPKNPTYGPNICDGNFDTVA MLRGEMFVFK ERWFWRVRNN QVMDGYPMPI GQFWRGLPAS INTAYERKDGKFVFFKGDKH WVFDEASLEP GYPKHIKELG RGLPTDKIDA ALFWMPNGKTYFFRGNKYYR FNEELRAVDS EYPKNIKVWE GIPESPRGSF MGSDEVFTYF YKGNKYWKFN NQKLKVEPGYPKSALRDWMG CPSGGRPDEG TEEETEVIII EVDEEGGGAV SHHHHHH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | ||
| Formulation | MMP14protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and10% glycerol. | ||
Matrix metalloproteinase-14 (MMP14), is a membrane-anchored zinc-binding endopeptidase which is expressed at the leading edge of differentinvasive carcinomas and also promotes tumor cell invasion through degradationof the extracellular matrix. MMP14 takesa vital part in extracellular matrix, ECM, remodeling by having the capabilityto degrade type I collagen, activate pro-MMP-2 and process cell adhesionmolecules for instance CD44 and integrin alpha V. MMP14 is a key enzyme in manyphysiological as well as pathological processes for example angiogenesis &tumor invasion.
Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.