MnTE-2-PyP chloride
(Synonyms: BMX-010 chloride) 目录号 : GC72995MnTE-2-PyP chloride是活性氧清除剂和有效的放射性保护剂。
Cas No.:219818-60-7
Sample solution is provided at 25 µL, 10mM.
MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porprin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.
MnTE-2-PyP (30 μM) protects against perglycemiainduced cell death after radiation[1]. MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1]. MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated perglycemic environment[1]. MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1].
MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer[1]. MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1].
References:
[1]. Arpita Chatterjee, et al. MnTE-2-PyP, a manganese porprin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses. Redox Biol. 2020 Jul;34:101542.
Cas No. | 219818-60-7 | SDF | |
别名 | BMX-010 chloride | ||
分子式 | C48H44Cl5MnN8 | 分子量 | 965.12 |
溶解度 | H2O : 12.5 mg/mL (12.95 mM; ultrasonic and warming and heat to 80°C) | 储存条件 | 4°C, sealed storage, away from moisture |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.0361 mL | 5.1807 mL | 10.3614 mL |
5 mM | 0.2072 mL | 1.0361 mL | 2.0723 mL |
10 mM | 0.1036 mL | 0.5181 mL | 1.0361 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet