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Modecainide (BMY 40327) Sale

(Synonyms: 莫地卡尼,BMY 40327; MJ 14030) 目录号 : GC32535

Modecainide (BMY 40327) 是 Encainide 的主要代谢物,Encainide 是一种抗心律失常药物。

Modecainide (BMY 40327) Chemical Structure

Cas No.:81329-71-7

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.

The effect of Encainide and its two major metabolites, O-demethylated Encainide (MJ 9444) and 3-O-methoxy Encainide (MJ 14030), on cardiac conduction is studied by recording His bundle potentials in isolated perfused rabbit hearts and Purkinje and muscle conduction in vivo in dog hearts after destruction of the atrioventricular node. Both metabolites are 4 to 15 times more potent than Encainide in slowing conduction through the atria, the AV-node and the His-Purkinje system of the rabbit heart. In the dog, Encainide (0.8-3.2 mg/kg i.v.) slows conduction of extrasystoles in both Purkinje and muscle at all coupling intervals, increases the effective refractory period and the functional refractory period of the Purkinje pathway. MJ 9444 (0.05-0.4 mg/kg) speeds Purkinje conduction of early (less than 300 msec) without affecting or while slowing conduction of late (greater than 350 msec) extrasystoles. Higher doses (0.4-1.6 mg/kg) slows conduction at all intervals. The effective refractory period and the functional refractory period are decreased but in some cases returned to control values at the higher doses. Muscle conduction is slowed at doses of 0.4 mg/kg or more. MJ 14030 (0.05-3.2 mg/kg) has variable effects, behaving like MJ 9444 in three experiments but like the parent compound in two others[1].

[1]. Dresel PE. Effect of encainide and its two major metabolites on cardiac conduction. J Pharmacol Exp Ther. 1984 Jan;228(1):180-6.

Chemical Properties

Cas No. 81329-71-7 SDF
别名 莫地卡尼,BMY 40327; MJ 14030
Canonical SMILES O=C(NC1=CC=CC=C1CCC2N(C)CCCC2)C3=CC=C(O)C(OC)=C3
分子式 C22H28N2O3 分子量 368.47
溶解度 Methanol : ≥ 250 mg/mL (678.48 mM); DMSO : 100 mg/mL (271.39 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7139 mL 13.5696 mL 27.1393 mL
5 mM 0.5428 mL 2.7139 mL 5.4279 mL
10 mM 0.2714 mL 1.357 mL 2.7139 mL
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