Moenomycin Complex

Moenomycin Complex is a mixture of moenomycin A, A₁₂, C₁, C₃ and C₄ isolated from several Streptomyces species that directly inhibit bacterial peptidoglycan glycosyltransferases (PGTs)^{[1, 2]}. Moenomycin A is a member of the phospholipid antibiotic family, which is the only known natural product that directly targets extracellular PGTs involved in bacterial cell wall biosynthesis^[3]. The minimum inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1 to 100ng/mL^[4]. Moenomycin can be used as a feed additive and growth promoter^[5].

References:
[1] Zehl M, Pittenauer E, Rizzi A, et al. Characterization of moenomycin antibiotic complex by multistage MALDI-IT/RTOF-MS and ESI-IT-MS[J]. Journal of the American Society for Mass Spectrometry, 2006, 17: 1081-1090.
[2] Yuan Y. Targeting the bacterial cell wall-structural insight into peptidoglycan glycosyltransferases and moenomycin inhibition[M]. Harvard University, 2008.
[3] Ostash B, Saghatelian A, Walker S. A streamlined metabolic pathway for the biosynthesis of moenomycin A[J]. Chemistry & biology, 2007, 14(3): 257-267.
[4] Ostash B, Walker S. Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity[J]. Natural product reports, 2010, 27(11): 1594-1617.
[5] Tang Y, Yang G, Ma Y, et al. Development, validation, and implementation of an ultratrace analysis method for the determination of moenomycin A, in aquatic animal products[J]. Analytical and Bioanalytical Chemistry, 2024, 416(3): 745-757.

Moenomycin Complex是莫诺霉素A、A₁₂、C₁、C₃和C₄的混合物，是从几种链霉菌中分离出来的，可直接抑制细菌肽聚糖糖基转移酶（PGT）^{[1, 2]}。Moenomycin A是磷脂类抗生素家族的成员，磷脂类抗生素是已知的唯一直接靶向参与细菌细胞壁生物合成的细胞外PGT的天然产物^[3]。Moenomycin A对各种革兰氏阳性菌的最低抑菌浓度范围为1-100ng/mL^[4]。Moenomycin能够用作饲料添加剂和生长促进剂^[5]。