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Moexipril-d5 Sale

目录号 : GC48469

An internal standard for the quantification of moexipril

Moexipril-d5 Chemical Structure

Cas No.:1356929-49-1

规格 价格 库存 购买数量
1mg
¥2,620.00
现货
5mg
¥11,804.00
现货
10mg
¥20,969.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat.1 It is converted to moexiprilat in vivo by side chain ester hydrolysis.2 Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively).2 Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.1 It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.3

1.Edling, O., Bao, G., Feelisch, M., et al.Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: Pharmacological characterization and comparison with enalaprilJ. Pharmacol. Exp. Ther.275(2)854-863(1995) 2.Cameron, R.T., Coleman, R.G., Day, J.P., et al.Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)Biochem. Pharmacol.85(9)1297-1305(2013) 3.Ravati, A., Junker, V., Kouklei, M., et al.Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and ratsEur. J. Pharmacol.373(1)21-33(1999)

Chemical Properties

Cas No. 1356929-49-1 SDF
Canonical SMILES [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CC[C@@H](C(OCC)=O)N[C@@H](C)C(N2CC3=CC(OC)=C(OC)C=C3C[C@H]2C(O)=O)=O
分子式 C27H29D5N2O7 分子量 503.6
溶解度 DMSO: soluble,Methanol: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.9857 mL 9.9285 mL 19.857 mL
5 mM 0.3971 mL 1.9857 mL 3.9714 mL
10 mM 0.1986 mL 0.9929 mL 1.9857 mL
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