Morin hydrate
(Synonyms: 桑色素.桑黄素) 目录号 : GN10253
Morin hydrate 是一种植物来源的类黄酮，具有低抗氧化活性。
Cas No.:6202-27-3
Sample solution is provided at 25 µL, 10mM.
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Morin hydrate is a plant flavonoid extracted from yellow Brazil wood with anti-oxidant properties. Previous studies have shown that morin hydrate could protect cells against oxygen radical damage.
In vitro: Morin hydrate at 75-100 µM protected against the oxidation of low density lipoprotein (LDL) induced by free radicals [1]. Morin hydrate at 100 μM concentration effectively inhibited Cu2+-induced oxidation of human LDL [2]. In cultured rat glomerular mesangial cells attacked by oxyradicals, the survival time of the cells was doubled with using morin hydrate [3]. 0.25 – 2.0 mM morin prolonged the survival of rat hepatocytes against free radical damage triggered by xanthine oxidase-hypoxanthine [4]. Morin hydrate could inhibit the amyloid formation by islet amyloid polypeptide and disaggregated amyloid fibers [5].
In vivo: In a 80 min ischemia rat model, treatment of morin at 2.5, 5.0 and 10 μmol/Kg reduced liver necrosis by 51.48 ± 9.94%, 66.55 ± 2.18%, and 79.37 ± 11.03%, respectively [3].
References:
[1].Wu T W, Fung K P, Wu J, et al. Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein[J]. Life sciences, 1995, 58(2): PL17-PL22.
[2].Wu T W, Fung K P, Yang C C, et al. Antioxidation of human low density lipoprotein by horin hydrate[J]. Life sciences, 1995, 57(3): PL51-PL56.
[3].Zeng L H, Fung K P, Wu T W. Morin hydrate protects cultured rat glomerular mesangial cells against oxyradical damage[J]. Life sciences, 1994, 55(18): PL351-PL357.
[4].Wu T W, Zeng L H, Wu J, et al. Morin hydrate is a plant-derived and antioxidant-based hepatoprotector[J]. Life sciences, 1993, 53(13): PL213-PL218.
[5].Noor H, Cao P, Raleigh D P. Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers[J]. Protein Science, 2012, 21(3): 373-382.
| Cas No. | 6202-27-3 | SDF | |
| 别名 | 桑色素.桑黄素 | ||
| 化学名 | 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one hydrate | ||
| Canonical SMILES | OC1=C(C(C(O)=C2)=CC=C2O)OC3=CC(O)=CC(O)=C3C1=O.O | ||
| 分子式 | C15H10O7.H2O | 分子量 | 320.25 |
| 溶解度 | DMSO : 64mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1226 mL | 15.6128 mL | 31.2256 mL |
| 5 mM | 0.6245 mL | 3.1226 mL | 6.2451 mL |
| 10 mM | 0.3123 mL | 1.5613 mL | 3.1226 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet