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Moxonidine Sale

(Synonyms: 莫索尼定; BDF5895) 目录号 : GC12629

An imidazoline I1 and α2A-adrenergic receptor agonist

Moxonidine Chemical Structure

Cas No.:75438-57-2

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥368.00
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10mg
¥483.00
现货
50mg
¥1,439.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Moxonidine is an agonist of I1-imidazoline receptor with EC50 value of 1.3µM [1].

Moxonidine can bind to both I1-imidazoline receptor (I1R) and α2-adrenergic receptor (α2AR). The selectivity of moxonidine for I1R is 33-fold over α2AR. Moxonidine plays its antihypertensive role in the central nervous system. It has a central site of action. It is shown no effect in pithed rats and in cats following spinal cord transaction. Moxonidine also reduces sympathetic outflow and lowers peripheral vascular resistence [1, 2].

Besides the antihypertensive efficacy, Moxonidine is reported to have effects on gastric secretion and gastric mucosal injury in rats. It significantly reduces basal gastric acid secretion when given doses of 0.1 (63% inhibition) and 1.0 (65% inhibition) mg/kg. Even 0.01mg/kg moxonidine can reduce the gastric mucosal injury induced by ethanol [3].

References:
[1] George OK, Gonzalez RR Jr, Edwards LP. Moxonidine, an antihypertensive agent, is permissive to alpha1-adrenergic receptor pathway in the rat-tail artery. J Cardiovasc Pharmacol. 2004 Feb;43(2):306-11.
[2] Morris ST, Reid JL. Moxonidine: a review. J Hum Hypertens. 1997 Oct;11(10):629-35.
[3] Glavin GB, Smyth DD. Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br J Pharmacol. 1995 Feb;114(4):751-4.

Chemical Properties

Cas No. 75438-57-2 SDF
别名 莫索尼定; BDF5895
化学名 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine
Canonical SMILES CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC
分子式 C9H12ClN5O 分子量 241.68
溶解度 ≥ 11.3 mg/mL in DMSO, ≥ 4.74 mg/mL in EtOH with ultrasonic 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.1377 mL 20.6885 mL 41.377 mL
5 mM 0.8275 mL 4.1377 mL 8.2754 mL
10 mM 0.4138 mL 2.0689 mL 4.1377 mL
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