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MPEP Sale

目录号 : GC10864

A potent, highly selective mGlu5a receptor antagonist

MPEP Chemical Structure

Cas No.:96206-92-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥378.00
现货
10mg
¥473.00
现货
50mg
¥1,733.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

MPEP is a selective and systemically active antagonist of metabotropic glutamate receptor subtype 5 (mGlu5 receptor) with IC50 value of 36nM [1].

MPEP is an antagonist of mGlu5 receptor. It is used as a valuable pharmacological tool to explore the function of its target receptor due to its high selectivity. In L (tk-) cells expressing human mGlu1b receptors, MPEP completely inhibits quisqualate-induced PI hydrolysis with IC50 value of 36nM. MPEP shows no effect in CHO-K1 cells expressing mGlu1b receptor or in L (tk-) mGlu5a cell line. In addition, 100μM MPEP also has no effect on group II and III mGlu receptor subtypes. Moreover, MPEP inhibits the DHPG induced PI hydrolysis in hippocampal, striatal and cortical slices with IC50 values of 8nM, 20.5nM and 17.9nM, respectively. Furthermore, microiontophoretical delivery of MPEP reduces DHPG-induced excitations in vivo. MPEP also shows anxiolytic-or antidepressant-like effects in the Vogel test in rats and in the tail suspension test in mice [1, 2].

References:
[1] Gasparini F, Lingenhöhl K, Stoehr N, et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology, 1999, 38(10): 1493-1503.
[2] Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, et al. Potential anxiolytic-and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. British journal of pharmacology, 2001, 132(7): 1423-1430.

Chemical Properties

Cas No. 96206-92-7 SDF
化学名 2-methyl-6-(2-phenylethynyl)pyridine
Canonical SMILES CC1=CC=CC(=N1)C#CC2=CC=CC=C2
分子式 C14H11N 分子量 193.24
溶解度 ≥ 9.95mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 5.1749 mL 25.8746 mL 51.7491 mL
5 mM 1.035 mL 5.1749 mL 10.3498 mL
10 mM 0.5175 mL 2.5875 mL 5.1749 mL
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