Mulberrin (Kuwanon C)
(Synonyms: 桑黄酮; Kuwanon C) 目录号 : GC32597
A flavone with diverse biological activities
Cas No.:62949-79-5
Sample solution is provided at 25 µL, 10mM.
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Kuwanon C is a prenylated flavone originally isolated from M. alba that has diverse biological activities, including antioxidant, antibacterial, antiproliferative, and neuroprotective properties.1 It scavenges DPPH radicals in a cell-free assay (EC50 = 72.99 ?g/ml).2 It is active against E. coli, S. typhimurium, S. epidermis, and S. aureus (MICs = 10, 25, 6.25, and 6.25 ?g/ml, respectively) and inhibits the growth of P388 mouse lymphoma cancer cells (IC50 = 14 ?g/ml).3,4 Kuwanon C (30 mg/kg) improves motor coordination in a rotarod test and decreases neuronal loss in the substantia nigra pars compacta in a mouse model of MPTP-induced Parkinson's disease.5
1.Nomura, T., Fukai, T., and Katayanagi, M.Kuwanon A, B, C and oxydihydromorusin, four new flavones from the root bark of the cultivated mulberry tree (Morus alba L.)Chem. Pharm. Bull.25(3)529-532(1977) 2.Mazimba, O., Majinda, R.R.T., and Motlhanka, D.Antioxidant and antibacterial constituents from Morus nigraAfr. J. Pharma. Pharmaco.5(6)751-754(2011) 3.Sohn, H.-Y., Son, K.H., Kwon, C.-S., et al.Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis NakaiPhytomedicine11(7-8)666-672(2004) 4.Ferlinahayati, Syah, Y.M., Juliawaty, L.D., et al.Phenolic constituents from the wood of Morus australis with cytotoxic activityZ. Naturforsch. C. J. Biosci.63(1-2)35-39(2008) 5.Cao, W., Dong, Y., Zhao, W., et al.Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson's disease by promoting Wnt/β-catenin signaling pathwayJ. Chem. Neuroanat.9863-70(2019)
| Cas No. | 62949-79-5 | SDF | |
| 别名 | 桑黄酮; Kuwanon C | ||
| Canonical SMILES | C/C(C)=C\CC1=C2C(C(C(C/C=C(C)\C)=C(C3=C(C=C(O)C=C3)O)O2)=O)=C(O)C=C1O | ||
| 分子式 | C25H26O6 | 分子量 | 422.47 |
| 溶解度 | DMSO: 100 mg/mL (236.70 mM) | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.367 mL | 11.8352 mL | 23.6703 mL |
| 5 mM | 0.4734 mL | 2.367 mL | 4.7341 mL |
| 10 mM | 0.2367 mL | 1.1835 mL | 2.367 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet