Myricetin 3-galactoside

Myricetin 3-galactoside is a flavonoid that has been found in M. communis and has diverse biological activities.^1,2 It inhibits xanthine oxidase in a cell-free assay when used at a concentration of 100 µg/ml.¹ Myricetin 3-galactoside is cytotoxic to K562 cells (IC₅₀ = 220 µg/ml) and inhibits hydrogen peroxide-induced malondialdehyde (MDA) formation in the same cells when used at concentrations of 110, 220, and 440 µg/ml.¹ In vivo, myricetin 3-galactoside (0.26 and 0.78 mg/kg) reduces carrageenan-induced paw edema in wild-type but not nos2^-/- mice.² It also reduces formalin-induced paw licking in mice.

1.Hayder, N., Bouhlel, I., Skandrani, I., et al.In vitro antioxidant and antigenotoxic potentials of myricetin-3-o-galactoside and myricetin-3-o-rhamnoside from Myrtus communis: modulation of expression of genes involved in cell defence system using cDNA microarrayToxicol. In Vitro22(3)567-581(2008) 2.de Oliveira Azevedo, A., Campos, J.J., de Souza, G.G., et al.Antinociceptive and anti-inflammatory effects of myricetin 3-O-β-galactoside isolated from Davilla elliptica: Involvement of the nitrergic systemJ. Nat. Med.69(4)487-493(2015)