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N-(3-hydroxyphenyl)-Arachidonoyl amide Sale

(Synonyms: 3-HPAA) 目录号 : GC15372

An irreversible COX-2 inhibitor

N-(3-hydroxyphenyl)-Arachidonoyl amide Chemical Structure

Cas No.:183718-75-4

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5mg
¥540.00
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10mg
¥1,016.00
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50mg
¥4,267.00
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100mg
¥7,440.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

IC50: 2 μM

N-(3-hydroxyphenyl) -Arachidonoyl amide, also known as 3-HPAA, is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide. 3-HPAA, metabolized by both cyclooxygenase (COX) -1 and COX-2, is an irreversible and selective inhibitor of COX-2 with an IC50 value of 2 M. 3-HPAA can be efficiently oxygenated to prostaglandin and hydroxyeicosatetraenoate products by prostaglandin endoperoxide synthase (PGHS) -2. It appears that 3-HPAA can be converted by PGHS-1 in a similar manner.

COX enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. COX enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them clinically important [1]. COX-2, overexpressed in cancer cells, promotes tumorigenesis and induces neo-angiogenesis. Additionally, it plays an important role in inflammation and pyrexia.

In vitro: Up to now, in vitro study of 3-HPAA is still in the development stage.

In vivo: Up to now, in vivo study of 3-HPAA is still in the development stage.

Reference:
[1].  Fitzpatrick, F. Cyclooxygenase Enzymes: Regulation and Function. Current Pharmaceutical Design. 2004; 10(6): 577-588.

Chemical Properties

Cas No. 183718-75-4 SDF
别名 3-HPAA
化学名 N-(3-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Canonical SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1cccc(O)c1
分子式 C26H37NO2 分子量 395.6
溶解度 ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5278 mL 12.639 mL 25.2781 mL
5 mM 0.5056 mL 2.5278 mL 5.0556 mL
10 mM 0.2528 mL 1.2639 mL 2.5278 mL
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