N-desmethyl Diltiazem (hydrochloride)
(Synonyms: 盐酸地尔硫卓杂质D) 目录号 : GC52132
An active metabolite of diltiazem
Cas No.:130606-60-9
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
N-desmethyl Diltiazem is an active metabolite of the calcium channel inhibitor diltiazem.1 It is formed from diltiazem by the cytochrome P450 (CYP) isoforms CYP3A4, CYP3A5, and CYP3A7.2 N-desmethyl Diltiazem binds to isolated rat cerebral cortex homogenates (IC50 = 323 nM) and inhibits spontaneous contractions in isolated rat portal veins (IC50 = 489 nM).1 It has been found as a contaminant in fresh water.3
1.Schoemaker, H., Hicks, P.E., and Langer, S.Z.Calcium channel receptor binding studies for diltiazem and its major metabolites: Functional correlation to inhibition of portal vein myogenic activityJ. Cardiovasc. Pharmacol.9(2)173-180(1987) 2.Williams, J.A., Ring, B.J., Cantrell, V.E., et al.Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7Drug Metab. Dispos.30(8)883-891(2002) 3.Marshall, M.M., and McCluney, K.E.Mixtures of co-occurring chemicals in freshwater systems across the continental USEnviron. Pollut.268(Pt. B)115793(2021)
Cas No. | 130606-60-9 | SDF | Download SDF |
别名 | 盐酸地尔硫卓杂质D | ||
Canonical SMILES | CC(O[C@@H]1[C@@](C2=CC=C(C=C2)OC)([H])SC3=CC=CC=C3N(C1=O)CCNC)=O.Cl | ||
分子式 | C21H24N2O4S ? HCl | 分子量 | 437 |
溶解度 | Chloroform: soluble,DMSO: soluble | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 2.2883 mL | 11.4416 mL | 22.8833 mL |
5 mM | 0.4577 mL | 2.2883 mL | 4.5767 mL |
10 mM | 0.2288 mL | 1.1442 mL | 2.2883 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。