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N-Docosanoyl Taurine Sale

目录号 : GC44354

A FAAH substrate discovered during metabolite profiling

N-Docosanoyl Taurine Chemical Structure

Cas No.:783284-48-0

规格 价格 库存 购买数量
1mg
¥1,147.00
现货
5mg
¥5,174.00
现货
10mg
¥9,181.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain. N-Docosanoyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice. The levels of N-docosanoyl taurine were elevated ~12 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-docosanoyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate that related N-fatty acyl taurines and ethanolamines of similar chain length are hydrolyzed 2,000-50,000 times more slowly by FAAH compared to oleoyl ethanolamide. N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.

化学性质

Cas No. 783284-48-0 SDF
Canonical SMILES CCCCCCCCCCCCCCCCCCCCCC(=O)NCCS(=O)(=O)O
分子式 C24H49NO4S 分子量 447.7
溶解度 DMF: 5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.25 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.2336 mL 11.1682 mL 22.3364 mL
5 mM 0.4467 mL 2.2336 mL 4.4673 mL
10 mM 0.2234 mL 1.1168 mL 2.2336 mL
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