N1-Me-pUTP,100mM Sodium Solution
(Synonyms: 三磷酸假尿苷,1-Methylpseudouridine-5′-triphosphate) 目录号 : GB20016
N1-Me-pUTP是天然存在的假尿苷pUTP的甲基修饰物,常用于RNA治疗和RNA疫苗合成。
Cas No.:1428903-59-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
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Purity: >95.00%
- COA (Certificate Of Analysis)
- Datasheet
N1-Methylpseudo-UTP (N1-Me-pUTP, m1ψ) is a methyl modification of naturally occurring pseudouridine (pseudo-UTP, pUTP), resulting from the N1-specific pseudouridine present in archaea and eukaryotes It is catalyzed by glycoside methyltransferase Nepl[1]. N1-Me-pUTP is a substitute for uridine (U) in RNA therapies and vaccines, which can effectively enhance RNA stability while reducing anti-RNA immune responses[2].
References:
[1]. Callum J C Parr, et al.N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells. 2020 Apr 6;48(6):e35. doi: 10.1093/nar/gkaa070.
[2]. Pedro Morais, Hironori Adachi, Yi-Tao Yu.The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines. 2021 Nov 4;9:789427. doi: 10.3389/fcell.2021.789427.
N1-Methylpseudo-UTP(N1-Me-pUTP,m1ψ)是天然存在的假尿苷(pseudo-UTP,pUTP)的甲基修饰物,由存在于古细菌和真核生物中的N1特异性假尿苷甲基转移酶Nepl催化生成[1]。N1-Me-pUTP在RNA治疗和疫苗中是尿苷(U)的替代物,能够有效增强RNA稳定性,同时降低抗RNA免疫应答[2]。
| Cas No. | 1428903-59-6 | SDF | |
| 别名 | 三磷酸假尿苷,1-Methylpseudouridine-5′-triphosphate | ||
| 分子式 | C10H14N2Na3O15P3 | 分子量 | 564.11 |
| 溶解度 | A solution of water | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7727 mL | 8.8635 mL | 17.727 mL |
| 5 mM | 0.3545 mL | 1.7727 mL | 3.5454 mL |
| 10 mM | 0.1773 mL | 0.8864 mL | 1.7727 mL |