N7-Me-GTP, 100mM Sodium Solution
目录号 : GB10790N7-Me-GTP是一种带正电荷的甲基修饰GTP,能够以共转录的方式添加到5′帽中。
Sample solution is provided at 25 µL, 10mM.
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N7-Methylguanosine-5'-triphosphate(N7-Me-GTP, m7G)is a positively charged RNA modification that is co-transcriptionally added to the 5′cap during the initial stages of transcription and prior to other RNA processing events[1]. N7-Me-GTP regulates the transcription, splicing, nuclear export and translation of mRNA, and plays an important role in gene expression, protein synthesis and transcript stability[2]. The N7-Me-GTP modification is also found in tRNA and rRNA, and its presence is associated with various diseases [2].
References:
[1]. Bowen Song, et al. m7GHub: deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human. Bioinformatics, Volume 36, Issue 11, June 2020, Pages 3528-3536.
[2]. Li-Sheng Zhang, et al. Transcriptome-wide Mapping of Internal N7-methylguanosine Methylome in Mammalian Messenger RNA. Published online 2019 Apr 25. DOI:10.1016/j.molcel.2019.03.036.
N7-Methylguanosine-5'-triphosphate(N7-Me-GTP, m7G)是一种带正电荷的修饰RNA,在转录的初始阶段和其他RNA加工事件之前以共转录方式添加到5′帽中[1]。N7-Me-GTP调节mRNA的转录、剪接、核输出和翻译,在基因表达、蛋白质合成和转录本稳定中起重要作用[2]。在tRNA和rRNA中也发现了N7-Me-GTP修饰,其存在与各种疾病有关[2]。
| purity | ≥99% | Extinction Coefficient | |
| 分子式 | C11H18N5O14P3(free acid) | 分子量 | 537.22(free acid) |
| Salt Form | Concentration | ||
| Buffer | 储存条件 | -20℃ | |
| Synonyms | N7-甲基鸟苷-5'-三磷酸 | Backbone | |
| Base Analog | Sugar Type | ||
| Nucleotide Category |