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Nat-20(S)-yne Sale

(Synonyms: Click Tag Nat-20(S)-yne) 目录号 : GC44321

Nat-20(S)-OHC with a terminal alkyne group

Nat-20(S)-yne Chemical Structure

Cas No.:1397692-46-4

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1mg
¥823.00
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5mg
¥3,701.00
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10mg
¥6,579.00
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25mg
¥14,390.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

Chemical Properties

Cas No. 1397692-46-4 SDF
别名 Click Tag Nat-20(S)-yne
Canonical SMILES O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@](O)(C)CCC#C
分子式 C25H38O2 分子量 370.6
溶解度 DMF: 14 mg/ml,DMSO: 0.5 mg/ml,Ethanol: 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.6983 mL 13.4916 mL 26.9833 mL
5 mM 0.5397 mL 2.6983 mL 5.3967 mL
10 mM 0.2698 mL 1.3492 mL 2.6983 mL
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