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Nateglinide-d5 Sale

(Synonyms: 那格列奈-D5,A4166 D5; Senaglinide D5) 目录号 : GC47751

An internal standard for the quantification of nateglinide

Nateglinide-d5 Chemical Structure

Cas No.:1227666-13-8

规格 价格 库存 购买数量
1 mg
¥3,340.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Nateglinide-d5 is intended for use as an internal standard for the quantification of nateglinide by GC- or LC-MS. Nateglinide is a hypoglycemic agent.1,2,3 It induces insulin and somatostatin release from perfused rat pancreas when used at concentrations ranging from 0.03 to 3 μM.1 Nateglinide (3 µM) increases intracellular calcium levels in isolated rat pancreatic β cells, an effect that can be inhibited by the L-type calcium channel blocker nitrendipine . Nateglinide-induced secretion of insulin and somatostatin and calcium influx is also reversed by the potassium channel activator diazoxide . Oral administration of nateglinide (1.6 mg/kg) reduces blood glucose levels by 20% in fasted mice.2 It also decreases blood glucose levels in an oral glucose tolerance test in normal rats, genetically diabetic KK mice, and a rat model of diabetes induced by streptozotocin .3 Formulations containing nateglinide have been used in the treatment of type 2 diabetes.

1.Fujitani, S., Ikenoue, T., Akiyoshi, M., et al.Somatostatin and insulin secretion due to common mechanisms by a new hypoglycemic agent, A-4166, in perfused rat pancreasMetabolism45(2)184-189(1996) 2.Shinkai, H., Toi, K., Kumashiro, I., et al.N-acylphenylalanines and related compounds. A new class of oral hypoglycemic agentsJ. Med. Chem.31(11)2092-2097(1988) 3.Sato, Y., Nishikawa, M., Shinkai, H., et al.Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animalsDiabetes Res. Clin. Pract.12(1)53-59(1991)

Chemical Properties

Cas No. 1227666-13-8 SDF
别名 那格列奈-D5,A4166 D5; Senaglinide D5
Canonical SMILES CC(C)[C@H]1CC[C@H](C(N[C@H](CC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(O)=O)=O)CC1
分子式 C19H22D5NO3 分子量 322.5
溶解度 DMSO : 100 mg/mL (310.13 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1008 mL 15.5039 mL 31.0078 mL
5 mM 0.6202 mL 3.1008 mL 6.2016 mL
10 mM 0.3101 mL 1.5504 mL 3.1008 mL
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