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NBTGR Sale

(Synonyms: 6-(4-硝基苄硫醇)鸟苷) 目录号 : GC32500

NBTGR(p-Nitrobenzylthioguanosine)是核苷转运(nucleosidetransport)的有效抑制剂;抑制腺苷摄取的Ki值为70nM。

NBTGR Chemical Structure

Cas No.:13153-27-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥1,865.00
现货
5mg
¥1,696.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM.

A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides[2].

[1]. Turnheim K, et al. Inhibition of adenosine uptake in human erythrocytes by adenosine-5'-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine. Biochem Pharmacol. 1978;27(18):2191-7. [2]. Parterson A, et al. Nucleoside Transport II Inhibition by p-Nitrobeazylthiogoanosine and Related Compounds. Can. J. Biochem. 49,271-274 (1971)

化学性质

Cas No. 13153-27-0 SDF
别名 6-(4-硝基苄硫醇)鸟苷
Canonical SMILES OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(N)N=C3SCC4=CC=C([N+]([O-])=O)C=C4)O1)O)O
分子式 C17H18N6O6S 分子量 434.43
溶解度 DMSO : 100 mg/mL (230.19 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 2.3019 mL 11.5093 mL 23.0187 mL
5 mM 0.4604 mL 2.3019 mL 4.6037 mL
10 mM 0.2302 mL 1.1509 mL 2.3019 mL
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