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Neoechinulin A Sale

目录号 : GC64126

Neoechinulin A 是一种异戊烯基吲哚生物碱,具有清除、神经营养因子样和抗凋亡活性。Neoechinulin A 诱导小鼠记忆改善和抗抑郁样作用。

Neoechinulin A Chemical Structure

Cas No.:51551-29-2

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1mg
¥3,600.00
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Sample solution is provided at 25 µL, 10mM.

Description

Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2].

Neoechinulin A (RAW264.7 macrophages; 3 hours; cells then stimulated with LPS (1 μg/mL) for 18 hours) suppresses PGE2, TNF-α, and IL-1β production in a dose-dependent manner[2].Neoechinulin A can suppress the production of pro-inflammatory mediators and cytokines including NO, PGE2, TNF-α, and IL-1β. Further, it reduced the expression of iNOS and COX-2 in LPS-stimulated RAW264.7 macrophages by inhibiting the NF-κB and p38 MAPK signaling pathways[2]. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity[3].

In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1].

[1]. Humbert M, et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010;5(3):e9430. Published 2010 Mar 4.
[2]. Kim KS, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013;18(11):13245-13259. Published 2013 Oct 25.
[3]. Dewapriya P, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013;35:30-40.

化学性质

Cas No. 51551-29-2 SDF Download SDF
分子式 C19H21N3O2 分子量 323.39
溶解度 储存条件 4°C, away from moisture and light
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1 mM 3.0922 mL 15.4612 mL 30.9224 mL
5 mM 0.6184 mL 3.0922 mL 6.1845 mL
10 mM 0.3092 mL 1.5461 mL 3.0922 mL
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