Nerol
(Synonyms: 橙花醇) 目录号 : GC40669
A monoterpene
Cas No.:106-25-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Nerol is a monoterpene and isomer of geraniol that has been found in a variety of plants, including Cannabis. It increases production of reactive oxygen species (ROS) and intracellular calcium levels and induces mitochondrial dysfunction, cytochrome C release, and apoptosis in A. flavus. Nerol (30-300 mg/kg) reduces weight loss, production of the inflammatory cytokines IL-13 and TNF-α, gastric damage, and hyperalgesia in a mouse model of oxazolone-induced colitis.
| Cas No. | 106-25-2 | SDF | |
| 别名 | 橙花醇 | ||
| Canonical SMILES | C/C(C)=C/CC/C(C)=C\CO | ||
| 分子式 | C10H18O | 分子量 | 154.3 |
| 溶解度 | DMSO : ≥ 100 mg/mL (648.30 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.4809 mL | 32.4044 mL | 64.8088 mL |
| 5 mM | 1.2962 mL | 6.4809 mL | 12.9618 mL |
| 10 mM | 0.6481 mL | 3.2404 mL | 6.4809 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Review of anticancer activity of monoterpenoids: Geraniol, Nerol, geranial and neral
Chem Biol Interact 2022 Aug 1;362:109994.PMID:35661738DOI:10.1016/j.cbi.2022.109994.
In recent years head-to-tail monoterpene geraniol has been widely explored as a potential anticancer agent. Natural analogs like alcohol Nerol, aldehydes geranial, and neral have been investigated. We explored the synergism of these terpenes with clinically and non-clinically used compounds as potential candidates for treating different types of cancer. Promising activity for these compounds has also inspired new analog syntheses. The anticancer potential of these compounds is described in this review.
Effects of Nerol on paracetamol-induced liver damage in Wistar albino rats
Biomed Pharmacother 2021 Aug;140:111732.PMID:34130201DOI:10.1016/j.biopha.2021.111732.
Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0.05% tween 80 dissolved in 0.9% NaCl solution (vehicle), paracetamol 640 mg/kg (negative control), 50 mg/kg silymarin (positive control), or Nerol (50 and 100 mg/kg) for 14 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers of the animals were collected and subjected to biochemical and microscopical analysis. The histological findings suggest that paracetamol caused lymphocyte infiltration and marked necrosis, whereas maintenance of the normal hepatic structural was observed in group pre-treated with silymarin and Nerol. The rats pre-treated with Nerol significantly and dose-dependently reduced the hepatotoxic markers in animals. Nerol at 100 mg/kg significantly reversed the paracetamol-induced altered situations, including the liver enzymes, plasma proteins, antioxidant enzymes and serum bilirubin, lipid peroxidation (LPO) and cholesterol [e.g., total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c)] levels in animals. Taken together, Nerol exerted significant hepatoprotective activity in rats in a dose-dependent manner. PCM-induced toxicity and Nerol induced hepatoprotective effects based on expression of inflammatory and apoptosis factors will be future line of work for establishing the precise mechanism of action of Nerol in Wistar albino rats.
Fragrance material review on Nerol
Food Chem Toxicol 2008 Nov;46 Suppl 11:S241-4.PMID:18640199DOI:10.1016/j.fct.2008.06.062.
A toxicologic and dermatologic review of Nerol when used as a fragrance ingredient is presented.
Biosynthesis of Nerol from glucose in the metabolic engineered Escherichia coli
Bioresour Technol 2019 Sep;287:121410.PMID:31076292DOI:10.1016/j.biortech.2019.121410.
In this study, Nerol was biosynthesized in the metabolic engineered Escherichia coli from glucose for the first time. Firstly, the truncated neryl diphosphate synthase gene tNDPS1 was expressed that catalyzes isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) to form neryl diphosphate (NPP), and then the Nerol synthase gene GmNES was co-expressed to synthesize the final product Nerol from NPP. The engineered strain LZ001 accumulated 0.053 ± 0.015 mg/L of Nerol. Secondly, the IDI1, MVD1, ERG8, ERG12, tHMG1 and ERG13 were co-expressed to increase the supply of IPP and DMAPP. Finally, the heterologous ERG10 gene was overexpressed, and the recombinant strain LZ005 produced 1.564 ± 0.102 mg/L of Nerol in shaking-flask culture, which represents a 29.51-fold increase over LZ001 strain. This study shows the novel method for the biosynthesis of Nerol and provides new metabolic engineering strategy for the production of terpenoids.
Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia
J Nat Prod 2017 Apr 28;80(4):1178-1181.PMID:28257200DOI:10.1021/acs.jnatprod.6b00888.
Two new antimicrobial agents, neryl ferulate (1) and neryl p-coumarate (2), were identified using bioassay-guided isolation from the leaves of Eremophila longifolia, which is a medicinal plant used by some Australian Aboriginal communities. Although gradual autoxidation of the Nerol subunit hindered the initial attempts to purify and characterize 1 and 2, it was found that the autoxidation could be stopped through storage under argon at -20 °C. Biological evaluation showed that neryl ferulate (1) had moderate activity against various Gram-positive bacteria, while neryl p-coumarate (2) was active only against Enterococcus faecium.