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Neticonazole hydrochloride Sale

(Synonyms: 盐酸奈替康唑) 目录号 : GC39409

Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.

Neticonazole hydrochloride Chemical Structure

Cas No.:130773-02-3

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥647.00
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25mg
¥585.00
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50mg
¥855.00
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100mg
¥1,440.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.

Chemical Properties

Cas No. 130773-02-3 SDF
别名 盐酸奈替康唑
Canonical SMILES CCCCCOC1=CC=CC=C1/C(N2C=CN=C2)=C\SC.[H]Cl
分子式 C17H23ClN2OS 分子量 338.9
溶解度 DMSO: 250 mg/mL (737.68 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.9507 mL 14.7536 mL 29.5072 mL
5 mM 0.5901 mL 2.9507 mL 5.9014 mL
10 mM 0.2951 mL 1.4754 mL 2.9507 mL
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Research Update

[Guidelines for diagnosis and treatment of mucocutaneous candidiasis]

Nihon Ishinkin Gakkai Zasshi 2009;50(4):207-12.PMID:19942790DOI:10.3314/jjmm.50.207.

This document summarizes current knowledge about diagnosis and treatment of candidiasis affecting the skin and oral mucosa. Several clinical forms of mucocutaneous candidiasis are distinguished depending on a patient's age and infected site, e.g. Candida intertrigo, erythema mycoticum infantile, erosio interdigitalis blastomycetica, candidal paronychia and onychia, Candida onychomycosis, and oral candidiasis. The diagnosis of candidiasis is confirmed by observation of mycelial forms on microscopic examination. Since Candida yeasts (especially C. albicans) are normal inhabitants of the skin and oral mucosa, it must always be noted that positive culture does not always indicate the presence of candidal infection. The pathogenicity of Candida species is relatively low, and some special conditions are required for tissue invasion by the fungus. Predisposing factors, such as disturbances of the cutaneous and mucosal microenvironment and systemic or local immunosuppression, should be checked in patients with recurrent infection. Therapy for cutaneous candidiasis is dominated by topical antifungal agents. Azole antifungal cream (e.g., bifonazole, ketoconazole, Neticonazole hydrochloride, lanoconazole and luliconazole) is most effective. Terbinafine hydrochloride and amorolfine hydrochloride are also useful. Cutaneous candidiasis usually requires a shorter duration of topical treatment (1-2 weeks) than superficial dermatophyte infections. For candidal paronychia and onychomycosis, oral therapy with itraconazole is recommended. The daily dose of itraconazole should be taken for several months, while its pulse therapy for candidiasis is not approved in Japan. Itraconazole oral solution is commonly used for oral candidiasis, and miconazole gel is also effective.

Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan

Int J Antimicrob Agents 2001 Aug;18(2):173-8.PMID:11516941DOI:10.1016/s0924-8579(01)00365-x.

In vitro anti-dermatophyte, anti-Candida albicans and anti-Malassezia furfur activities of amorolfine hydrochloride (AMF), terbinafine hydrochloride (TBF), butenafine hydrochloride (BTF), Neticonazole hydrochloride (NCZ) and ketoconazole (KCZ), all of which were introduced for the treatment of dermatomycoses in the 1990s in Japan, were compared. Although all of the test drugs are classified as an ergosterol biosynthesis inhibitor, the antifungal properties were found to be different. TBF and BTF exerted extremely potent antifungal activity against Trichophyton spp. but not against C. albicans and M. furfur, whilst KCZ and NCZ showed potent antifungal activity against C. albicans and M. furfur rather than Trichophyton spp. AMF exhibited potent antifungal activity against all of the fungal species tested. Fungicidal activities of these antifungal agents against T. rubrum were determined by using neutral red staining. The fungicidal potentialities correlated with those obtained in the in vitro susceptibility test as determined by MICs against dermatophytes. TBF, BTF and AMF exerted more potent fungicidal action than NCZ and KCZ.

[Two cases of Trichophyton mentagrophytes infection contracted from a hamster and a chinchilla]

Nihon Ishinkin Gakkai Zasshi 2000;41(4):269-73.PMID:11064327DOI:10.3314/jjmm.41.269.

We report two cases of Trichophyton mentagrophytes infection. Case 1: A 10-year-old girl visited Tokyo Electric Power Hospital in June 1994 for evaluation of an erythematous lesion on her head. Three months of topical steroid therapy exacerbated the lesion with pustular formation. Histopathological and mycological examination revealed that the patient had tinea capitis caused by T. mentagrophytes. T. mentagrophytes was also isolated from her pet, a hamster. Case 2: A-14-year-old girl was referred to Shonan Clinic in January 1996 with scaly erythema on her face. She had been treated with Neticonazole hydrochloride at another clinic, but the lesion became worse. Direct microscopic examination of the scale was negative at that time, so treatment with topical steroid was started. After 10 days, the lesion was almost cured, but one month later it recurred with an annular distribution. KOH preparation of the scale revealed mycelia and T. mentagrophytes was isolated on culture. T. mentagrophytes was also isolated from her pet, a chinchilla. In both cases, the oral administration of itraconazole at 50 mg/day was effective. The isolated pathogen was identified as Arthroderma vanbreuseghemii with species-specific primers of chitin synthase 1 gene. T. mentagrophytes is one of the most common dermatophytes isolated from man and animals. Rodents like the hamster and the chinchilla have recently become popular as pets in Japan. We should be aware that rodents may carry this kind of fungal pathogen as they become even more popular as pets.