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Neuropeptide Y (human) (TFA) Sale

目录号 : GC61499

NeuropeptideY(human)TFA和阿尔兹海默症相关,能够保护老鼠皮质神经元对抗淀粉样蛋白毒性。

Neuropeptide Y (human) (TFA) Chemical Structure

规格 价格 库存 购买数量
1 mg
¥1,620.00
现货
5 mg
¥6,480.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

It is showed that Neuropeptide Y (human) is able to protect cortical neurons from Aβ25-35 toxicity. 2 μM NPY abolishes the toxic effects of Aβ25-35 at 24 and 48 h. The same effect on neuronal survival is observed in neurons exposed to 1 μM and 0.5 μM Neuropeptide Y (human) pretreatments. Pretreatment with Neuropeptide Y (29-64), amide, human (TFA) Increases NGF Synthesis, reduces NGF mRNA, and restores NGF release in cortical neurons exposed to Aβ35-25[1].

[1]. Croce N, et al. Neuropeptide Y protects rat cortical neurons against β-amyloid toxicity and re-establishes synthesis and release of nerve growth factor. ACS Chem Neurosci. 2012 Apr 18;3(4):312-8.

Chemical Properties

Cas No. SDF
分子式 C191H286F3N55O59S 分子量 4385.7
溶解度 储存条件 Store at -20°C, protect from light, stored under nitrogen
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.228 mL 1.1401 mL 2.2801 mL
5 mM 0.0456 mL 0.228 mL 0.456 mL
10 mM 0.0228 mL 0.114 mL 0.228 mL
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Research Update

Solution synthesis of human neuropeptide Y (hNPY)

Chem Pharm Bull (Tokyo) 1989 Jul;37(7):1925-9.PMID:2805172DOI:10.1248/cpb.37.1925

Human neuropeptide Y (hNPY) was synthesized in a conventional manner by assembling seven peptide fragments followed by reduction of the Met(O) residue with phenylthiotrimethylsilane and subsequent deprotection with 1 M trimethylsilyl trifluoromethanesulfonate (TMSOTf)-thioanisole in trifluoroacetic acid (TFA). Alternatively, deprotection was performed in a two-step manner; first, treatment with 1 M trimethylsilyl bromide-thioanisole in TFA, and then with 1 M TMSOTf-thioanisole in TFA. After purification by gel-filtration on Sephadex G-25, followed by reversed-phase high-performance liquid chromatography, a highly purified sample of synthetic hNPY was obtained in both cases. When administered in dogs, synthetic hNPY was as active as porcine NPY in terms of the effects on systemic arterial blood pressure, pancreatic blood flow, and superior mesentric artery (SMA) blood flow. Met(O)17-hNPY was found to be as active as the parent sample in these bioassays.