Home>>Signaling Pathways>> Immunology/Inflammation>> nNOS>>NG-amino-L-Arginine (hydrochloride)

NG-amino-L-Arginine (hydrochloride) Sale

目录号 : GC15316

Inhibitor of NOS enzymes

NG-amino-L-Arginine (hydrochloride) Chemical Structure

Cas No.:1031799-40-2

规格 价格 库存 购买数量
5mg
¥729.00
现货
10mg
¥1,348.00
现货
25mg
¥3,188.00
现货
50mg
¥5,631.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

NG-amino-L-arginine, a novel structural analog of L-arginine, is an inhibitor of nitric oxide synthase (NOS) [1,2]. Nitric oxide synthases (NOSs) have been involved in catalyzing the production of nitric oxide (NO) from L-arginine. As an important cellular signaling molecule, NO has been implicated in modulating vascular tone, airway tone, insulinsecretion, and peristalsis. It has also been shown that NO is involved in angiogenesis and neural development and can function as a retrograde neurotransmitter [3].

In vitro: NG-amino-L-arginine potently and stereoselectively induced endothelium-dependent contraction. NG-amino-L-arginine caused concentration-dependent, competitive, and stereoselective antagonism of acetylcholine-elicited relaxation and cyclic GMP accumulation. NG-Amino-L-arginine was 100- to 300- fold more potent than NG-methyl-L-arginine [1]. NG-amino-L-arginine (100 μM) almost abolished endothelium-dependent relaxation induced by acetylcholine, but was rapidly restored by addition of 300 μM L-arginine. The maximal response to acetylcholine was inhibited by NG-amino-L-arginine in excess of 1 μM and was abolished by concentrations in the range of l0-30 μM [1]. NG-Amino-L-arginine inactivated the citrulline-forming activity of the nNOS, iNOS, and eNOS isoforms with the maximal inactivation rates of 0.35, 0.26, and 0.53 min-1 and Ki values of 0.3, 3, and 2.5 μM, respectively [2].

In vivo: In awake animal models of sepsis, treatment with NG-amino-L-arginine showed higher systemic and pulmonary vascular resistance indices and decreased heart rates, cardiac indices, oxygen delivery indices, and oxygen consumption indices when compared with controls [4]. NG-amino-L-arginine increased mortality rates after endotoxin challenge [4].

References:
[1] Fukuto J M, Wood K S, Byrns R E, et al.  NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation[J]. Biochemical and biophysical research communications, 1990, 168(2): 458-465.
[2] Wolff D J, Lubeskie A.  Inactivation of Nitric Oxide Synthase Isoforms by Diaminoguanidine andN G-Amino-L-arginine[J]. Archives of biochemistry and biophysics, 1996, 325(2): 227-234.
[3] Frstermann U, Closs E I, Pollock J S, et al.  Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions[J]. Hypertension, 1994, 23(6 Pt 2): 1121-1131.
[4] Cobb J P, Natanson C, Hoffman W D, et al.  N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin[J]. Journal of Experimental Medicine, 1992, 176(4): 1175-1182.

Chemical Properties

Cas No. 1031799-40-2 SDF
化学名 N5-(hydrazinyliminomethyl)-L-ornithine, monohydrochloride
Canonical SMILES NNC(NCCC[C@H](N)C(O)=O)=N.Cl
分子式 C6H15N5O2 • HCl 分子量 225.7
溶解度 ≤10mg/ml in PBS(pH7.2) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 4.4307 mL 22.1533 mL 44.3066 mL
5 mM 0.8861 mL 4.4307 mL 8.8613 mL
10 mM 0.4431 mL 2.2153 mL 4.4307 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置