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NG,NG-dimethyl-L-Arginine (hydrochloride)

(Synonyms: 不对称二甲基精氨酸二盐酸盐溶液,100PPM,ADMA) 目录号 : GC17237

An endogenous NOS inhibitor

NG,NG-dimethyl-L-Arginine (hydrochloride) Chemical Structure

Cas No.:220805-22-1

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5mg
¥333.00
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10mg
¥634.00
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25mg
¥1,491.00
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50mg
¥2,617.00
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Sample solution is provided at 25 µL, 10mM.

Description

NG,NG-dimethyl-L-Arginine is an endogenous nitric oxide synthase inhibitor.

Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence.

In vitro: NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].

In vivo: Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].

Clinical trial: Local infusion of ADMA into the brachial artery of healthy volunteers caused a dose-dependent fall in forearm blood-flow. Infusion of ADMA for 5 min resulted in a fall in forearm blood-flow in 5 subjects, and the effects of this ADMA dose were significantly attenuated by infusion of L-arginine [1].

Reference:
[1] Vallance, P. ,Leone, A.,Calver, A., et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339, 572-575 (1992).

化学性质

Cas No. 220805-22-1 SDF
别名 不对称二甲基精氨酸二盐酸盐溶液,100PPM,ADMA
化学名 N5-[(dimethylamino)iminomethyl]-L-ornithine, dihydrochloride
Canonical SMILES OC(=O)[C@@H](N)CCCNC(=N)N(C)C
分子式 C8H18N4O2 • 2HCl 分子量 275.2
溶解度 DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 20 mg/ml; Water: 20 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 3.6337 mL 18.1686 mL 36.3372 mL
5 mM 0.7267 mL 3.6337 mL 7.2674 mL
10 mM 0.3634 mL 1.8169 mL 3.6337 mL
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