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NL-1 Sale

目录号 : GC39411

The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.

NL-1 Chemical Structure

Cas No.:188532-26-5

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10mM (in 1mL DMSO)
¥747.00
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10mg
¥675.00
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50mg
¥2,340.00
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Sample solution is provided at 25 µL, 10mM.

Description

The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.

NL-1 is a mitoNEET inhibitor with antileukemic effect, which induces a concentration-dependent decrease in cell viability of REH and REH/Ara-C, and impaires the migratory ability of leukemic cells irrespective of the chemoattractant used.[2]

NL-1 shows antileukemic activity in an in vivo mouse ALL model.[2]

[1] Geldenhuys WJ, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):819-23. [2] Geldenhuys WJ, et al. J Pharmacol Exp Ther. 2019 Jul;370(1):25-34.

化学性质

Cas No. 188532-26-5 SDF
Canonical SMILES O=C(N1)SC(CC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)C1=O
分子式 C18H25NO3S 分子量 335.46
溶解度 DMSO: 250 mg/mL (745.25 mM) 储存条件 Store at -20°C
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1 mM 2.981 mL 14.9049 mL 29.8098 mL
5 mM 0.5962 mL 2.981 mL 5.962 mL
10 mM 0.2981 mL 1.4905 mL 2.981 mL
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