NMM Human
目录号 : GP24054Non-Muscle Myosin-II Regulatory Light Chain Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Non-Muscle Myosin-II Regulatory Light Chain; NMM. | ||
| Amino Acid Sequence | MSSKKAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID KEDLHDMLAS LGKNPTDAYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE DVIRNAFACF DEEATGTIQE DYLRELLTTM GDRFTDEEVD ELYREAPIDK KGNFNYIEFT RILKHGAKDK DD. | ||
| Stability | Store vial at -20°C to -80°C . When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles. | ||
| Biological Activity | Assayed for phosphorilation by MLCK. | ||
| Formulation | NMM protein at 0.2mg/ml in 20mM HEPES-KOH, pH7, 50mM NaCl, 1mM EDTA and 1mM DTT. | ||
Non muscle Myosins are required for cytokinesis at the end of cell division, when a contractile ring near the plasmalemma divides the cytoplasm of the daughter cells. They are involved in cytoplasmic streaming movements in tissues, and especially in activation of motile cells such as fibroblasts and macrophages. Activation of non-muscle myosin-II is achieved by phosphorylation of Ser33 in the motif KKRPQRATSN by a dedicated, Ca +2 Calmodulin regulated light chain kinase (MLCK).
Assayed for phosphorilation by MLCK.
Store vial at -20°C to -80°C . When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.