Nonadecanoic Acid
(Synonyms: 正碳十九酸) 目录号 : GC44447
A 19-carbon saturated fatty acid
Cas No.:646-30-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Nonadecanoic acid is a 19-carbon saturated fatty acid that is found in fats and vegetable oils. It has been shown to inhibit HL-60 cancer cell proliferation with an IC50 value of 68 μM.
| Cas No. | 646-30-0 | SDF | |
| 别名 | 正碳十九酸 | ||
| Canonical SMILES | OC(CCCCCCCCCCCCCCCCCC)=O | ||
| 分子式 | C19H38O2 | 分子量 | 298.5 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.25 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3501 mL | 16.7504 mL | 33.5008 mL |
| 5 mM | 0.67 mL | 3.3501 mL | 6.7002 mL |
| 10 mM | 0.335 mL | 1.675 mL | 3.3501 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
A new lupane-type triterpenoid fatty acid ester and other isolates from Ophiorrhiza shendurunii
Nat Prod Res 2016 Oct;30(19):2197-203.PMID:26979490DOI:10.1080/14786419.2016.1160232.
A new pentacyclic triterpenoid fatty acid ester, lupan-20-ol-3(β)-yl hexadecanoate (1), together with lupan-20-ol-3(β)-yl acetate (2), olean-18-en-3(β)-yl hexadecanoate (3), dotriacontanoic acid (4), stigmasterol (5), rubiadin (6), Nonadecanoic Acid (7), palmitic acid (8) and camptothecin (9) were isolated from the hexane and chloroform extracts of Ophiorrhiza shendurunii from South India. Structures of the isolates were determined by (1)H, (13)C, (13)C DEPT, (1)H-(1)H COSY, HMBC, HSQC, NOESY NMR, FT-IR, DART-MS, ESI-MS, alkaline hydrolysis, derivatisation, GC-MS and HPTLC analyses. O. shendurunii hexane and chloroform extracts showed significant activities against Candida albicans and Fusarium oxysporum. Compounds 1 to 3 showed only moderate antiyeast/antifungal activities.
Phenolics, tocopherols and fatty acid profiling of wild and commercial mushrooms from Pakistan
J Biol Regul Homeost Agents 2018 Jul-Aug;32(4):863-867.PMID:30043568doi
Mushrooms can be used as nutraceutical or functional foods to maintain and promote good health. In the present study, wild Ganoderma lucidum and four commercial mushrooms, Pleurotus ostreatus, Volvariella volvacea, Hericium erinaceus and Lentinus edodes, collected from Pakistan were screened for phenolics, tocopherols and fatty acid contents. High performance liquid chromatography analysis of phenolic acids showed that chlorogenic acid, ferulic acid, gallic acid, p-Coumaric and caffeic acids were observed in selected mushrooms. H. erinaceus contained high amounts of chlorogenic acid (11.49±0.1 µ/g of dry weight) and ferulic acid (7.84±0.7 µg/g of dry weight). γ-tocopherol and lutein were present in all studied mushrooms. Lutein contents were higher in H. erinaceus (2.42±0.087 µg/g of DW) followed by V. volvacea> P. ostreatus> L. edodes. γ-tocopherol was observed in the range of 74.25±3.01 to 29.65±1.2 µg/g of dry weight. GC/MS analysis of fatty acids showed that linoleic acid (18:2n6c), oleic acid (18:1n9c), palmitic acid (C16:0), stearic acid (C18:0), linolenic acid (18:3n3) and Nonadecanoic Acid (C19-0), were the main fatty acids found in selected mushrooms. The unsaturated fatty acids were predominated over saturated fatty acids. It is concluded that selected mushrooms are good sources of antioxidant compounds and unsaturated fatty acids.
Manipulation of fatty acid composition in animal cells grown in culture
Proc Natl Acad Sci U S A 1973 Dec;70(12):3669-73.PMID:4519656DOI:10.1073/pnas.70.12.3669.
The fatty acid composition of animal cells cultured in serum-free medium can be manipulated when the synthesis of endogenous fatty acids is inhibited by a biotin analog and fatty acids are supplied in the medium as detergent esters of Tween. When mouse LM cells were grown in medium supplemented with Tween-19:0 (an ester of Tween and Nonadecanoic Acid), odd chain fatty acid content of cellular phospholipids and neutral lipids increased from 1% to 75%. Concurrently, the saturated fatty acid content increased from 27% to 85%. Similar alterations in fatty acid content have been observed when BHK(21) cells are subjected to the same enrichment regime. The ability to control the fatty acid composition of cultured animal cells is a prerequisite to investigations into the role of the membrane lipid physical state in processes unique to these cells.
Identification of anti-hepatic fibrosis components in Periplaneta americana based on spectrum-effect relationship and chemical component separation
Biomed Chromatogr 2022 Mar;36(3):e5286.PMID:34837247DOI:10.1002/bmc.5286.
Periplaneta americana (PA) is used as a traditional medicine for hepatic diseases such as hepatic fibrosis in China. However, the relationship between the corresponding therapeutic effect and the chemical composition is still unclear. In this study, spectrum-effect relationship and chemical component separation were used to discover the potential of anti-hepatic fibrosis components of PA. The fingerprints of 10 batches of samples were established using HPLC, and the anti-hepatic fibrosis effect was determined using HSC-T6 cells. The spectrum-effect relationship between common peaks and efficacy values was established using partial least squares analysis. Partial peaks in the fingerprints were identified, including X4 (9,12-heptadecanedenoic acid glyceride), X5 (Nonadecanoic Acid methyl ester), X6 (glyceryl oleate), X7 (13,16,19-eicosatrienoic acid), X9 (linoleic acid), X10 (9,12,15-octadecatrienoic acid glyceride), X12 (hexadecanoic acid), X13 (oleic acid), and X14 (octadecanoic acid), and their anti-hepatic fibrosis activity was tested to verify the results of spectrum-effect relationships. The results showed that X4 , X6 , X7 , and X10 were the active ingredients of PA. This work successfully identified the partial anti-hepatic fibrosis components of PA, which can be used to explain the material basis for the PA anti-hepatic fibrosis effect.
[Fatty acid composition of blood plasma lipids and erythrocytes in lung cancer patients]
Vopr Med Khim 1994 Sep-Oct;40(5):48-50.PMID:7839672doi
The fatty acid spectrum of blood plasma and erythrocytic membrane lipids were studied in 47 patients with lung cancer. The changes in the plasma and erythrocyte fatty acid composition were found to be identical irrespective of the clinical cancer form. In blood plasma of these patients with lung cancer, a decrease in the level of polyunsaturated fatty acids was observed with the normal levels of arachidonic acid and the proportion of monoenic fatty acids was increased. Changes in the lipid composition of erythrocyte membranes were characterized by less pronounced polyunsaturated fatty acid deficiency than that in the plasma, which accompanied by decreases in arachidonic acid levels. The appearance of significant levels of Nonadecanoic Acid also seems striking.