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Norbergenin Sale

(Synonyms: Norbergenin; Demethylbergenin,) 目录号 : GC19765

Norbergenin 是 bergenin 的 O-去甲基衍生物,具有中等的抗氧化活性(在 DPPH 自由基清除中 IC50 为 13 μM;在超氧阴离子清除中为 32 μM)。

Norbergenin  Chemical Structure

Cas No.:79595-97-4

规格 价格 库存 购买数量
5mg
¥250.00
现货
25mg
¥750.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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实验参考方法

Kinase experiment [1]:

Inhibition of TH activity: Norbergenin inhibits the bovine adrenal TH activity by 51.0% at 5 μg/mL, 51.6% at 10 μg/mL, 53.4% at 20 μg/mL, respectively.

Cell experiment [2]:

Cell lines

Neuronal cells (Rat)

Preparation method

The solubility of this compound in DMSO is > 1 mM..

Reaction Conditions

3 days

Applications

Norbergenin can enhance antioxidant activity, which can be further related to protecting neurons from damage by ROS

Animal experiment [3]:

Animal models

balb/c mice

Dosage form

5, 10, 20, 40 and 80 mg/kg per oral dose

Applications

Norbergenin inhibit Th1 (IL-2, IFN-γ and TNF-α) and up-regulates Th2 cytokines (IL-4 and IL-5) significantly, and release the symptom of oedema at 40 and 80 mg/kg.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1] Nazir N, et al. J Ethnopharmacol. 2007 Jun 13;112(2):401-5.

[2] Zhang YH, et al. Phytother. Res. 2003 Sep;17(8):967-9.

[3] Takahashi H, et al. Bioorg. Med. Chem. 2003 Apr 17;11(8):1781-8.

产品描述

Norbergenin, an O-demethylated derivative of bergenin, can be isolated from rhizomes of Bergenia stacheyi.

Norbergenin shows anti-arthritic activity through modulation of Th1/Th2 cytokine balance, and it inhibits the production of proinflammatory Th1 cytokines (IL-2, IFN-γ and TNF-α) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice.[1]

Norbergenin inhibits bovine adrenal tyrosine hydroxylase (TH) activity by 29.0% and 53.4% at a concentration of 20 μg/mL, and exhibited noncompetitive inhibition of TH activity with the substrate L-tyrosine. [2]

Norbergenin shows moderate antioxidant activity (IC50 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging). [3]

Reference:
[[1] Nazir N, et al. J Ethnopharmacol. 2007 Jun 13;112(2):401-5.
[2] Zhang YH, et al. Phytother. Res. 2003 Sep;17(8):967-9.
[3] Takahashi H, et al. Bioorg. Med. Chem. 2003 Apr 17;11(8):1781-8.

Chemical Properties

Cas No. 79595-97-4 SDF
别名 Norbergenin; Demethylbergenin,
化学名 Pyrano(3,2-c)(2)benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,9,10-pentahydroxy-2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,4aalpha,10bbeta))-
Canonical SMILES O=C1C2=CC(O)=C(O)C(O)=C2[C@@]3([H])[C@]([C@@H](O)[C@H](O)[C@@H](CO)O3)([H])O1
分子式 C13H14O9 分子量 314.246
溶解度 DMSO : 125 mg/mL (397.79 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1822 mL 15.9111 mL 31.8222 mL
5 mM 0.6364 mL 3.1822 mL 6.3644 mL
10 mM 0.3182 mL 1.5911 mL 3.1822 mL
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