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Norgestimate-d6 Sale

(Synonyms: 炔诺肟酯-D6) 目录号 : GC47797

An internal standard for the quantification of norgestimate

Norgestimate-d6 Chemical Structure

Cas No.:1263194-12-2

规格 价格 库存 购买数量
500 μg
¥1,661.00
现货
1 mg
¥3,161.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Norgestimate-d6 is intended for use as an internal standard for the quantification of norgestimate by GC- or LC-MS. Norgestimate is a progestin and a prodrug form of norelgestromin and levonorgestrel .1,2 It binds to progestin receptors (mean IC50 = 3.48 nM for rabbit uterine receptors) and is selective for progestin over androgen receptors (mean IC50 = 764 nM for rat prostatic receptors) in radioligand binding assays.3 Norgestimate maintains pregnancy in ovariectomized female rats in a dose-dependent manner.1 It inhibits ovulation in 100% of female rats when administered at a dose of 0.5 mg/kg. Norgestimate (2 mg/kg) completely inhibits estrone-induced vaginal cornification in ovariectomized female rats, indicating antiestrogenic activity. Formulations containing norgestimate in combination with ethinyl estradiol have been used as oral contraceptives and in the treatment of acne vulgaris.

1.Hahn, D.W., Allen, G.O., and McGuire, J.L.The pharmacological profile of norgestimate, a new orally active progestinContraception16(5)541-553(1977) 2.Stanczyk, F.Z.All progestins are not created equalSteroids68(10-13)879-890(2003) 3.Phillips, A., Demarest, K., Hahn, D.W., et al.Progestational and androgenic receptor binding affinities and in vivo activities of norgestimate and other progestinsContraception41(4)399-410(1990)

Chemical Properties

Cas No. 1263194-12-2 SDF
别名 炔诺肟酯-D6
Canonical SMILES CC[C@@]12[C@](CC[C@@]2(OC(C)=O)C#C)([H])[C@]3([H])CC([2H])([2H])C4=C([2H])/C(C([2H])([2H])C[C@]4([2H])[C@@]3([H])CC1)=N/O
分子式 C23H25D6NO3 分子量 375.5
溶解度 Methanol: soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 2.6631 mL 13.3156 mL 26.6312 mL
5 mM 0.5326 mL 2.6631 mL 5.3262 mL
10 mM 0.2663 mL 1.3316 mL 2.6631 mL
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