NRTN Human
目录号 : GP20767Neurturin Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 96.0% as determined by: | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Neurturin. | ||
| Amino Acid Sequence | ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV | ||
| Solubility | It is recommended to reconstitute the lyophilized NRTN in sterile 18MΩ-cm H2O not less than 0.5mg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized NRTN although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution NRTN should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). | ||
| Biological Activity | Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA. | ||
| Formulation | NRTN protein was lyophilized from a 0.2 µm filtered concentrated solution in 30 mM Citrate Sodium, pH 4.2, 400 mM NaCl, with 0.02 % Tween-20. | ||
NRTN belongs to the GDNF family of ligands, a distant member of the TGF-beta superfamily. NRTN, a ligand used to bind to GFRA2 receptors, signals through RET and a GPI-linked coreceptor, and promotes endurance of neuronal populations, controls the size of non-neuronal cell population such as haemopoietic cells and regulate the development and maintenance of the CNS. Mutation in NRTN results in Hirschsprung Disease.
Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA.
Lyophilized NRTN although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution NRTN should be stored at 4°C between 2-7 days and for future use below -18°C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).